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IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2...

Shen(X),Hong(F),Nguyen(V A),Gao(B) FEBS Lett 2000-11-07

...SOCS3, and cytokine-inducible SH2 protein (CIS) mRNA expression in the liver. Furthermore, overexpression of SOCS2 or SO...

SOCS: physiological suppressors of cytokine signaling.

Krebs(D L),Hilton(D J) J Cell Sci 2000-10-19

...SOCS3 suggests that SOCS3 negatively regulates fetal liver erythropoiesis, probably through its ability to modulate eryt...

Negative regulation of cytokine signaling pathways.

Yasukawa(H),Sasaki(A),Yoshimura(A) Annu Rev Immunol 2000-07-12

...SOCS3, and JAB/SOCS1) negatively regulate cytokine signal transduction by various means: CIS1 inhibits STAT5 activation ...

Activation of downstream signals by the long form of the leptin receptor.

Banks(A S),Davis(S M),Bates(S H),Myers(M G... J Biol Chem 2000-06-08

...SOCS3 message accumulation. Tyr(985)-mediated recruitment of SHP-2 does not alter tyrosine phosphorylation of Jak2 or ST...

Mechanism of STAT3 activation by insulin-like growth factor I receptor.

Zong(C S),Chan(J),Levy(D E),Horvath(C),Sad... J Biol Chem 2000-06-21

...SOCS3 and CIS, was able to inhibit the IGF-I-induced STAT3 activation as well with varying degrees of potency, in which ...

Cytokine signaling through Stat3 activates integrins, promotes adhesion, and ...

Wooten(D K),Xie(X),Bartos(D),Busche(R A),L... J Biol Chem 2000-09-25

...SOCS3 expression abrogates homotypic cell aggregation, signaling through CD18-containing integrins, G(1) arrest, and acc...

LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STA...

Bode(J G),Nimmesgern(A),Schmitz(J),Schaper... FEBS Lett 2000-01-19

...SOCS3 mRNA in each of the investigated type of macrophages but not in HepG2 cells. Using a specific inhibitor, evidence ...

Role of the suppressor of cytokine signaling-3 in mediating the inhibitory ef...

Boisclair(Y R),Wang(J),Shi(J),Hurst(K R),O... J Biol Chem 2000-03-16

...SOCS3 mRNA by 8-fold after 24 h of treatment, whereas GH had no effect. Forced expression of SOCS3 was just as effective...

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction thr...

Schmitz(J),Weissenbach(M),Haan(S),Heinrich... J Biol Chem 2000-06-02

...SOCS3-mRNA levels, whereas increased expression of SOCS3 results in a reduction of SHP2 phosphorylation after activation...

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase ...

Sasaki(A),Yasukawa(H),Suzuki(A),Kamizono(S... Genes Cells 1999-10-14

...SOCS3) that inhibits signalling of various cytokines. However, the mechanism of JAK signal inhibition by CIS3 has not be...

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