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Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase an...

Lee(Richard G),Kelley(Kathryn L),Sawyer(Ja... Circ Res 2005-05-27

...ACAT2 would lead to absence of plasma CEs and reduced atherosclerosis. To test this hypothesis, ACAT2-/- LCAT-/- LDLr-/-...

Acyl coenzyme A:cholesterol acyltransferase inhibitors as hypolipidemic and a...

Alegret(M),Llaverias(G),Silvestre(J S) Methods Find Exp Clin Pharm... 2005-02-02

...ACAT2, have been described. ACAT1 is ubiquitously found, with high expression levels in macrophages, adrenals, sebaceous...

ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying en...

Parini(Paolo),Davis(Matthew),Lada(Aaron T)... Circulation 2005-05-27

...ACAT2 inhibitor, pyripyropene A, in microsomal activity assays demonstrated that ACAT2 activity was highly variable amon...

Control of ACAT2 liver expression by HNF1.

Pramfalk(Camilla),Davis(Matthew A),Eriksso... J Lipid Res 2005-10-21

...ACAT2 (also known as Soat1 and Soat2). In adult humans, ACAT1 is present in most tissues, whereas ACAT2 is localized to ...

Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-ba...

Lada(Aaron T),Davis(Matthew),Kent(Carol),C... J Lipid Res 2004-09-27

...ACAT2 are enzymes responsible for the formation of cholesteryl esters in tissues. While both ACAT1 and ACAT2 are present...

Human acyl-coenzyme A:cholesterol acyltransferase expressed in chinese hamste...

Lin(Song),Lu(Xiaohui),Chang(Catherine C Y)... Mol Biol Cell 2004-02-20

...ACAT2) have been identified. The expression of ACAT1 is ubiquitous, whereas that of ACAT2 is tissue restricted. Previous...

Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:ch...

Temel(Ryan E),Gebre(Abraham K),Parks(John ... J Biol Chem 2004-01-12

...ACAT2 were 1.6 and 7.2, respectively. Compared with ACAT1, ACAT2 selectively esterified cholesterol even when sitosterol...

Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholestero...

Liang(John J),Oelkers(Peter),Guo(Cuiying),... J Biol Chem 2004-12-14

...ACAT2-expressing cells treated with OA. These studies indicate that increasing DGAT1, ACAT1, or ACAT2 expression in McA-...

ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: ...

Repa(Joyce J),Buhman(Kimberly K),Farese(Ro... Hepatology 2004-11-19

...ACAT2(+/+) mice and from 1.0 +/- 0.2 to 5.5 +/- 0.6 in those without ACAT2. In the ACAT2(+/+) mice, hepatic cholesterol ...

Evidence for substantial effect modification by gender in a large-scale genet...

McCarthy(Jeanette J),Meyer(Joanne),Moliter... Hum Genet 2004-03-23

...ACAT2, ITGB3, F2 and SELP ( P values ranging from 0.032 to 0.002). Only one gene ( PRCP) was significantly associated in...

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