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TREM2 as a central hub of neuroimmune-metabolic crosstalk in central nervous sy…

Wu(Y),Duan(L),Zhang(L),Wang(S),Yan(H),He(M),… Front Immunol 2026-00-00

...SYK pathway, PLCγ2-mediated Ca2+ signaling, PI3K-AKT-mTOR signaling, NF-κB activation and inflammatory regulatory pathwa...

Postbiotic Enterococcus faecalis EF-2001 induces IL-10 production through macro…

Kubota(Y),Tsuboya(T),Murakami(M),Uehara(S),S… Front Immunol 2026-00-00

...Syk and PI3K inhibition substantially reduced EF-2001 phagocytosis. The inhibition of Syk, PI3K, and MAPKs hampered IL-1...

AI-Assisted Discovery and Optimization of Small-Molecule TREM2 Agonists with Fu…

Cho(S),Szalai(TV),El Gaamouch(F),Bajusz(D),K… ACS Med Chem Lett 2026-02-12

...SYK phosphorylation in TREM2-expressing cells, and promoted microglial phagocytosis. Together, these findings establish ...

The small-molecule Syk inhibitor R788 inhibits hematopoiesis and worsens anemia…

Parachalil Gopalan(B),Kamimura(S),Dagur(P),L… Blood Vessel Thromb Hemost 2026-02-00

...Syk) signaling pathway is a key driver of NETosis, we investigated the effect of targeting Syk with fostamatinib (R788)....

Integrating Machine Learning and Structure-Guided Discovery of a Novel Type II …

Li(Z),Lu(Y),Zhang(S),Zhao(W),Wu(T),Li(Z),Wan… J Med Chem 2026-07-09

Spleen tyrosine kinase (SYK) is a cytoplasmic nonreceptor kinase involved in immune signaling and homologous recombinati...

Regulatory role of Fc receptor in mIgM+ B lymphocyte phagocytosis in common car…

Hao(Y),Ding(C),Ma(J),Liu(X) Fish Shellfish Immunol 2026-09-00

...Syk inhibitor markedly reduced the phagocytic capacity of mIgM+ B lymphocytes against antiserum-opsonized bacteria compa...

Codonopsis pilosula polysaccharide attenuates the inflammatory response in macr…

Wang(X),Zhou(Z),Zhang(N),Zhang(Z),Qi(X),Zhan… Front Immunol None

...SYK/FAK/AKT phosphorylation, PKC activation, and WNT-1 signaling pathway transduction. Additionally, CPPS modulated the ...

Entanglement production in the Sachdev-Ye-Kitaev model and its variants.

Pathak(T),Tezuka(M) Phys Rev E 2026-05-00

...SYK and binary SYK, absent in spin operators of the spin-SYK model. Numerically, we find that these differences emerge g...

Chrysin reprograms microglial metabolism and function via targeting SYK to alle…

Li(L),Gu(Y),Luo(X),Wang(J),Jia(Y),Yan(T) J Ethnopharmacol 2026-11-15

...SYK-dependent. Chrysin is the primary brain-permeable constituent of AE. that targets SYK to restore microglial metaboli...

Exploring the immunomodulatory potential of Lilium lancifolium in pneumonia: a …

Li(D),Wang(L),Bao(Y),Wu(H),Sun(H),Zhang(W) Sci Rep 2026-06-20

...SYK) associated with representative flavonoids, including quercetin, kaempferol, and hesperetin. Enrichment analysis ind...

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