Literature Search

Wataya-Kaneda(Mari) J Dermatol Sci 2016-05-05

...TSC1 or TSC2. Inhibitors of mTORC1, such as rapamycin, effectively suppress the symptoms of TSC. This article summarizes...

Prabhakar(Shilpa),Zhang(Xuan),Goto(June),Han… Neurobiol Dis 2016-08-19

...Tsc1(cc) (homozygous for a conditional floxed Tsc1 allele) SynI-cre(+), in which Tsc1 is lost selectively in neurons sta...

Fang(Fang),Sun(Shaogang),Wang(Li),Guan(Jun-L… J Bone Miner Res 2016-03-25

...Tsc1 and the sequelae of Tsc1 dysfunction in bone are unknown. In this study, we generated a mouse model of TSC with a d...

Leech(Jarrett D),Lammers(Stephen H T),Goldma… Mol Cancer Res 2016-02-01

...TSC1 or TSC2. TSC-associated tumor growth is present in multiple tissues and organs including brain, kidney, liver, hear...

Lin(Hui-Ping),Lin(Ching-Yu),Huo(Chieh),Jan(Y… Oncotarget 2016-08-15

...TSC1 (tuberous sclerosis 1) and TSC2 (tuberous Sclerosis Complex 2) proteins in PC-3 PCa cells. Overexpression of AKT3 a...

Sundberg(Maria),Sahin(Mustafa) J Child Neurol 2016-08-15

...Tsc1 and Tsc2 that link cerebellar circuitry to the development of autistic-like features. Taken together, these preclin...

Angliker(Nico),Burri(Michael),Zaichuk(Marian… Eur J Neurosci 2016-08-03

...TSC1 revealed a striking overlap in Purkinje cell degeneration and death, which included neurofilamentopathy and reactiv...

Wu(Huijuan),Chen(Jianchun),Xu(Jinxian),Dong(… J Am Soc Nephrol 2016-08-11

...Tsc1 and rpS6 double-mutant mice. Furthermore, pharmacologic treatment of Tsc1 single-mutant mice with rapamycin reduced...

Hu(Zhongdong),Wang(Ying),Huang(Fuqiang),Chen… J Biol Chem 2016-02-16

...Tsc1 knock-out mice were abolished by mTOR inhibitor rapamycin. Furthermore, BEX2 was also increased in the liver of a h...

Meyer(Claudius U),Kurlemann(Gerhard),Sauter(… Neuropediatrics 2016-06-24

...tsc1/tsc2 genes leave mTOR uninhibited, a positive downstream modulator of the innate proinflammatory immune system, whi...