...TSC2 knockdown had the opposite effect. These results reveal that the mTOR signaling pathway regulates MSC immunobiology...
...Tsc2 form the tuberous sclerosis complex (TSC), a regulator of mTOR activity. Tsc1 stabilizes Tsc2; however, the precise...
...TSC2 to regulate TOR activity. Depletion of Atg9 caused a marked decrease in TSC2 levels. Our findings revealed an antag...
...TSC2 in the DNA of peripheral leukocytes identified a novel TSC2 c.3599G>C (p.R1200P) variant. Functional assessment con...
...TSC2 mutations in isolated HME demonstrating a "two-hit" model. Mutations in the same gene cause a disease continuum fro...
...TSC2 mutation was detected in 2 families. A total of 3 TSC-RAML patients underwent partial nephrectomy due to a high ble...
...TSC2 both of which are part of insulin signaling pathway. These results may shed light on the initiation and development...
...TSC2, 10 (29%) had mutations in TSC1, while 5 (15%) had no mutation identified in TSC1/TSC2. The majority of these sampl...
...TSC2 gene. Diagnosis is based on well-established clinical criteria or genetic criteria. Clinical features are highly va...
...tsc2 -/-, we demonstrate that toxin-triggered autophagy inhibits host cell proliferation, which contributes to TcdB-caus...
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