...TSC2/1 pathway linking activation of AMPK to inhibition of mTOR. Histopathological and biochemical studies of breast can...
...TSC2, are at increased risk for intellectual disability and/or autism. Features of epilepsy, neuropathology, genetics, a...
...TSC2 predispose to angiomyolipomas and lymphangioleiomyomatosis in a mTOR-dependent manner. In these mesenchymal lesions...
...TSC2 mutation (c.311-312insGCTG) in the patient from family 1, and a probably pathogenic TSC2 mutation (c.1790A>G) in th...
...TSC2 genes, leading to constitutive activation of the mammalian target of rapamycin (mTOR) signaling pathway. Cortical t...
...TSC2-deficient (TSC2-/-) mice. TSC2-/- mice were born normally at the expected Mendelian ratio. However, the median life...
...TSC2, NF1, FBXW7) were explored.,Sequencing data was obtained from tumors of 55 of the 73 enrolled pts. Mutation rates w...
...TSC2(Ser1254) decreased while ERK1/2 and TSC2(Thr1462) increased age-dependently. Furthermore, our data show that the mT...
...TSC2 complex, an inhibitor of the mTOR signaling pathway, with a central role in cell growth and autophagy. The top gene...
...TSC2 proteins. According to western blotting data, LIF withdrawal leads to phosphorylation of TSC2 protein thereby relie...
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