...TSC2 mutations on brain development. Tubers may represent the most dramatic developmental abnormality in TSC; however, m...
...TSC2 promotes benign tumors and neurological and behavioral deficits, a syndrome known as tuberous sclerosis (TS). In Dr...
...TSC2-mTORC1 pathway has recently been described for PPARγ expression in adipocytes. In our experiments, TNFα upregulatio...
...TSC2-deficient or TSC2-overexpressing monocytes, respectively. Finally, in vivo depletion of macrophages was sufficient ...
...TSC2, p38, and NFκβp65. Conversely, 7 other proteins are commonly decreased: ATRIP, ATR, β-catenin, BCL-X, cyclin B1, Eg...
...Tsc2 gene underlies TSC pathogenesis, but involvement of specific neural cell populations in the formation of TSC-associ...
...TSC2]) were performed to assess autophagy. We found that overexpression of Nampt increased autophagy (LC3 puncta immunoc...
...Tsc2(+/-) and Fmr1(-/y) mice, here we show that synaptic dysfunction caused by these mutations actually falls at opposit...
...TSC2 protein complex. To study the regulation of mTORC2 activity, it is a common practice to examine the phosphorylation...
Tuberous sclerosis complex (TSC) is an autosomal dominant disease caused by mutations in either of two genes, TSC1 or TS...
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