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Cytoarchitectural alterations are widespread in cerebral cortex in tuberous scl…

Marcotte(Leah),Aronica(Eleonora),Baybis(Mari… Acta Neuropathol 2012-08-01

...TSC2 mutations on brain development. Tubers may represent the most dramatic developmental abnormality in TSC; however, m...

Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not To…

Dimitroff(Brian),Howe(Katie),Watson(Adrienne… PLoS One 2012-09-24

...TSC2 promotes benign tumors and neurological and behavioral deficits, a syndrome known as tuberous sclerosis (TS). In Dr...

Inhibition of adipogenesis and induction of apoptosis and lipolysis by stem bro…

Dave(Sandeep),Kaur(Naval Jit),Nanduri(Ravika… PLoS One 2012-06-04

...TSC2-mTORC1 pathway has recently been described for PPARγ expression in adipocytes. In our experiments, TNFα upregulatio...

Macrophage-induced tumor angiogenesis is regulated by the TSC2-mTOR pathway.

Chen(Wei),Ma(Tao),Shen(Xu-ning),Xia(Xue-feng… Cancer Res 2012-05-14

...TSC2-deficient or TSC2-overexpressing monocytes, respectively. Finally, in vivo depletion of macrophages was sufficient ...

Protein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown…

Levin(Victor A),Panchabhai(Sonali),Shen(Li),… Proteome Sci 2012-10-02

...TSC2, p38, and NFκβp65. Conversely, 7 other proteins are commonly decreased: ATRIP, ATR, β-catenin, BCL-X, cyclin B1, Eg...

Sustained activation of mTOR pathway in embryonic neural stem cells leads to de…

Magri(Laura),Cambiaghi(Marco),Cominelli(Manu… Cell Stem Cell 2012-04-09

...Tsc2 gene underlies TSC pathogenesis, but involvement of specific neural cell populations in the formation of TSC-associ...

Induction of autophagy contributes to the neuroprotection of nicotinamide phosp…

Wang(Pei),Guan(Yun-Feng),Du(Hui),Zhai(Qi-Wei… Autophagy 2012-06-06

...TSC2]) were performed to assess autophagy. We found that overexpression of Nampt increased autophagy (LC3 puncta immunoc...

Mutations causing syndromic autism define an axis of synaptic pathophysiology.

Auerbach(Benjamin D),Osterweil(Emily K),Bear… Nature 2012-02-23

...Tsc2(+/-) and Fmr1(-/y) mice, here we show that synaptic dysfunction caused by these mutations actually falls at opposit...

An in vitro assay for the kinase activity of mTOR complex 2.

Huang(Jingxiang) Methods Mol Biol 2012-03-16

...TSC2 protein complex. To study the regulation of mTORC2 activity, it is a common practice to examine the phosphorylation...

A genetic model to dissect the role of Tsc-mTORC1 in neuronal cultures.

Nie(Duyu),Sahin(Mustafa) Methods Mol Biol 2012-03-16

Tuberous sclerosis complex (TSC) is an autosomal dominant disease caused by mutations in either of two genes, TSC1 or TS...

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