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mTOR-dependent modulation of gastric nesfatin-1/NUCB2.

Li(Ziru),Xu(Geyang),Li(Yin),Zhao(Jing),Mulho… Cell Physiol Biochem 2012-08-09

...TSC2 reduced the expression of nesfatin-1/NUCB2 in Min-6 cells, suggesting a direct effect of mTOR signaling.,Gastric mT...

Identification of TSC1 and TSC2 mutations in Korean patients with tuberous scle…

Jang(Mi-Ae),Hong(Seung Bong),Lee(Jee Hun),Le… Pediatr Neurol 2012-08-08

Tuberous sclerosis complex is a genetic disorder caused by mutations in the genes TSC1 or TSC2. Studies of these mutatio...

Tuberous sclerosis and epilepsy: role of astrocytes.

Wong(Michael),Crino(Peter B) Glia 2012-11-07

...TSC2 mutations and astrocytic proliferation. Astrocytic proliferation in subependymal giant cell astrocytoma is associat...

Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTO…

Li(Zhuo),Miard(Stéphanie),Laplante(Mathieu),… Mol Cell Endocrinol 2012-09-28

...TSC2 or 4E-BP1. Insulin triggered the recruitment of CAAT/enhancer binding protein α (C/EBPα) to the IGFBP-2 proximal pr...

Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 si…

Hong-Brown(Ly Q),Brown(C Randell),Kazi(Abid … Am J Physiol Cell Physiol 2012-07-23

...TSC2/Rheb pathway. Treatment of myocytes with EtOH (100 mM) decreased protein synthesis, whereas Leu (2 mM) increased sy...

TSC2 modulates cell adhesion and migration via integrin-α1β1.

Moir(Lyn M),Black(Judith L),Krymskaya(Vera P) Am J Physiol Lung Cell Mol Ph… 2012-12-26

...TSC2, enhances both cell proliferation and migration. Although substantial progress has been made in understanding the r...

Tuberin inhibits production of the matrix protein fibronectin in diabetes.

Habib(Samy L),Yadav(Mukesh),Tizani(Shaza),Bh… J Am Soc Nephrol 2012-12-13

...TSC2(+/-) ) diabetic rats than wild-type diabetic rats. Furthermore, TSC2(+/-) rats exhibited significant increases...

Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and e…

Tanwar(Pradeep S),Kaneko-Tarui(Tomoko),Zhang… PLoS Genet 2012-12-17

...Tsc2, regulators of mTORC1 that are downstream of LKB1 signaling, in the oviductal and uterine stroma phenocopies some o...

Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Dr…

Dragojlovic-Munther(Michelle),Martinez-Agost… Development 2012-12-03

...Tsc2 or Pten deficiency in progenitors increases TOR signaling and causes LG overgrowth by increasing the number of acti...

Uterine angiosarcoma associated with lymphangioleiomyomatosis in a patient with…

Hayashi(Takuo),Koike(Kengo),Kumasaka(Toshio)… Hum Pathol 2012-11-29

A 41-year-old woman carrying a germline tuberous sclerosis complex 2 (TSC2) mutation, whose regular medical follow-up fo...

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