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Catalysis of ACAT may be completed within the plane of the membrane: a workin...

Chang(T Y),Chang(C C),Lu(X),Lin(S) J Lipid Res 2002-03-05

...ACAT2 in intestinal cholesterol absorption. On the other hand, the functional roles of ACAT1 and ACAT2 in the VLDL or ch...

Differential expression of ACAT1 and ACAT2 among cells within liver, intestin...

Lee(R G),Willingham(M C),Davis(M A),Skinne... J Lipid Res 2001-03-01

...ACAT2. Both are membrane-spanning proteins believed to reside in the endoplasmic reticulum of cells. ACAT2 has been hypo...

ACAT1 and ACAT2 membrane topology segregates a serine residue essential for a...

Joyce(C W),Shelness(G S),Davis(M A),Lee(R ... Mol Biol Cell 2001-02-02

A second form of the enzyme acyl-CoA:cholesterol acyltransferase, ACAT2, has been identified. To explore the hypothesis ...

Resistance to diet-induced hypercholesterolemia and gallstone formation in AC...

Buhman(K K),Accad(M),Novak(S),Choi(R S),Wo... Nat Med 2001-01-08

...ACAT2 is the major ACAT in mouse small intestine and liver, and suggest that ACAT2 deficiency has profound effects on ch...

Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and h...

Wilcox(L J),Borradaile(N M),de Dreu(L E),H... J Lipid Res 2001-08-30

...ACAT2. However, in HepG2 cells, ACAT2 mRNA was selectively decreased (- 50%, P < 0.001) by both flavonoids, whereas ACAT...

Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2.

Chang(T Y),Chang(C C),Lin(S),Yu(C),Li(B L)... Curr Opin Lipidol 2001-08-09

...ACAT2. There is compelling evidence implicating a role for ACAT1 in macrophage foam-cell formation, and for ACAT2 in int...

Acyl-CoA:cholesterol acyltransferase inhibition reduces atherosclerosis in ap...

Kusunoki(J),Hansoty(D K),Aragane(K),Fallon... Circulation 2001-07-19

...ACAT2 (expressed in liver and intestine) activities reduces atherosclerosis development in apoE-deficient mice and avoid...

A major locus for fasting insulin concentrations and insulin resistance on ch...

Duggirala(R),Blangero(J),Almasy(L),Arya(R)... Am J Hum Genet 2001-06-07

...ACAT2, 6q25.3-q26). In sum, we found substantial evidence for susceptibility loci on chromosome 6q that influence insuli...

Differential modulation of ACAT1 and ACAT2 transcription and activity by long...

Seo(T),Oelkers(P M),Giattina(M R),Worgall(... Biochemistry 2001-07-12

...ACAT2 mRNA. FFA had no affect on ACAT1 mRNA in THP1 cells. To determine if FFAs affect ACAT1 or ACAT2 posttranscriptiona...

Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and fun...

Rudel(L L),Lee(R G),Cockman(T L) Curr Opin Lipidol 2001-05-31

...ACAT2 is present only in hepatocytes and in intestinal mucosal cells. The membrane topology for ACAT1 and ACAT2 is also ...

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