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INPP5K limits PtdIns (4,5)P2 accumulation in CD19 microclusters and restrains C…

Moës(B),Mostafa(A),Malempré(R),Renson(O),Pie… Front Immunol 2026-00-00

...SYK) were unchanged or reduced. INPP5K deficiency also increased basal CD19 and BCR microcluster formation, impaired CD1...

TREM2 regulates neuroinflammation by SYK-dependent inhibition of BTK activation…

Zhang(K),Chi(W),Guo(J),Huang(Y),Zhang(Z),Guo… Int Immunopharmacol 2026-03-15

...SYK phosphorylation to inhibit BTK activity, an effect antagonized by the SYK inhibitor R406. Subsequent studies indicat...

Vasicine Attenuates Allergic Asthma by Suppressing Mast Cell Degranulation and …

Qu(L),Du(W),Ren(Z),Chen(M),Wu(X),Cao(X),Rao(… Pharmaceuticals (Basel) 2026-01-22

...Syk/MAPK pathway. Conclusions: These findings indicate that Vas may effectively alleviate allergic asthma by reducing in...

Effects of PFOA and emerging alternatives at environmental concentrations on mu…

Wu(K),Zhou(S),Tang(A),Tao(J),Chen(Y),Zhou(H)… Environ Res 2026-03-01

...SYK signaling were determined. BMD data showed that PFOA exhibited greater neurotoxic potential than GenX and PFBS follo...

Identification and computational assessment of novel targeting sites of dexamet…

Dwivedi(SD),Rathor(LS),Singh(D),Singh(MR) In Silico Pharmacol None

...Syk), Interferon (IFN)-γ, Nicotinamide phosphoribosyl transferase (NAMPT) or Visfatin, NF-κB receptors which are respons...

Genome-Wide Insights into Intermittent Milking Behavior of Pandharpuri Buffalo.

Patil(A),Gaur(P),Pal(P),Alex(R),Chhotaray(S)… Curr Issues Mol Biol 2026-01-19

...SYK, INSR, PTPN11, VAV3, MAPK3, and PRKG1. These signatures provide insights into genomic regions and biological pathway...

Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflamm…

Chen(H),Xu(S),Chen(B),Xiong(X),Hu(J),Wu(Y),W… J Diabetes Investig 2026-03-00

...Syk/CARD9/IRF5/NF-κB pathway, reduced macrophage and neutrophil infiltration, and suppressed inflammatory cytokine expre...

Unveiling the gut-brain axis: How chronic exposure to arsenic-induced microglia…

Qu(J),Jiang(X),Ma(Y),Sheng(X),Pi(C),Wang(Y),… J Hazard Mater 2026-02-01

...SYK and CD36). Furthermore, SiAhR treatment could alleviated microglial inflammatory injury and enhancing the microglia'...

The involvement of CLec-HTM/IgR-Syk-BCL10-mTOR/ERK signaling pathway in immune …

Sun(J),Wu(W),Zhang(T),Wang(Z),Guo(Z),Yao(H),… J Immunol 2026-01-21

...Syk-BCL10 signaling pathway was interfered by silencing the expression of the main components, the phosphorylation of mT...

TREM2 activation by first-in-class direct small molecule agonists: DEL screenin…

Nada(H),Yuan(S),El Gaamouch(F),Cho(S),Kuncew… Eur J Med Chem 2026-01-15

...Syk phosphorylation, luciferase assay and enhanced microglial phagocytosis. Pre-liminary optimization yielded 4i, which ...

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