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mTORC2 is required for proliferation and survival of TSC2-null cells.

Goncharova(Elena A),Goncharov(Dmitry A),Li(H… Mol Cell Biol 2011-09-06

...TSC2-null cell proliferation and survival through RhoA GTPase and Bcl2 proteins. TSC2-null cell proliferation was inhibi...

Pml represses tumour progression through inhibition of mTOR.

Bernardi(Rosa),Papa(Antonella),Egia(Ainara),… EMBO Mol Med 2011-08-09

...Tsc2 allele. Interestingly, however, aberrant TORC1 activity does not accelerate renal cystogenesis in Tsc2/Pml mutants....

Regulation of T-cell survival and mitochondrial homeostasis by TSC1.

O'Brien(Thomas F),Gorentla(Balachandra K),Xi… Eur J Immunol 2011-12-02

...TSC2 complex has been shown to inhibit mTORC1 signaling in cell line models. We show here that deletion of TSC1 in the m...

Selective gene expression profiling of mTOR-associated tumor suppressor and onc…

Laudański(Piotr),Kowalczuk(Oksana),Klasa-Maz… Folia Histochem Cytobiol 2011-10-27

...TSC2, KRAS, RPS6KB1, 4EBP1, TP53, EIF4E, STK11, PIK3CA and BECN1. Confirmatory immunohistochemical detection was perform...

Magnetic resonance imaging of renal involvement in genetically studied patients…

Pompili(Giovanni),Zirpoli(Salvatore),Sala(Ch… Eur J Radiol 2010-02-02

...TSC2 patients, cysts were found in 2/4 TSC1 and in 9/15 TSC2 patients. The global renal involvement ranged from 0 to 32%...

[TSC2/PKD1 contiguous gene syndrome. Report of two cases].

Yadaden(Tarik),Molinié(Vincent),Ples(Raluca)… Ann Pathol 2010-04-22

...TSC2/PKD1 contiguous gene syndrome". It has been described essentially in young children. We report 2 new cases in Frenc...

Cardiac rhabdomyoma in tuberous sclerosis: hyperactive Erk signaling.

Jozwiak(Jaroslaw),Sahin(Mustafa),Jozwiak(Ser… Int J Cardiol 2010-08-24

...TSC2 gene. To analyze molecular mechanisms implicated in rhabdomyoma growth, we determined the status of mTOR, Akt and E...

Mechanisms of TSC-mediated control of synapse assembly and axon guidance.

Knox(Sarah),Ge(Hong),Dimitroff(Brian D),Ren(… PLoS One 2010-04-19

...TSC2; it is characterized by hamartomatous tumors, and is associated with severe neurological and behavioral disturbance...

[Analysis of gene mutations in two patients with tuberous sclerosis complex].

Yuan(Cheng-Da),Chang(Xiao-Li),Wu(Yao-Qun),Li… Zhongguo Yi Xue Ke Xue Yuan X… 2010-05-11

...TSC2 genes of these two patients, unaffected member in the two families, and 100 unrelated population-matched controls w...

Increased frequency of distinct TSC2 allelic variants in focal cortical dysplas…

Schönberger(Anna),Niehusmann(Pitt),Urbach(Ho… Neuropathology 2010-01-13

...TSC2 allelic variants but not TSC1 (intron 31: 60% vs. 11% in controls; P = 0.0164, exon 41: 40% vs. 6.5% in controls; P...

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