...TSC2 tumor suppressor contributes to suppression of mTORC1; however, TSC2-deficient cells remain responsive to energy st...
...TSC2- and mTOR-independent localization defect of the mutant protein. We conclude that although TSC1 missense mutations ...
...tsc2, indicating that S6K acts downstream or in parallel to TOR in differentiation as in growth. However, loss of eIF4E ...
...TSC2). In the lung, LAM cells found in the vicinity of cysts are, at times, localized in nodules and may be responsible ...
...Tsc2 mutant) rat model of hereditary renal cancer and confirmed the efficacy of gene silencing in vitro. Then, by using ...
...TSC2 in which brain involvement causes epilepsy, mental retardation, and autism. We have reported recently (Meikle et al...
TSC1 and TSC2 are the tumour-suppressor genes mutated in the tumour syndrome TSC (tuberous sclerosis complex). Their gen...
...Tsc2 in beta cells (betaTsc2(-/-)). These mice exhibited decreased glucose levels and hyperinsulinemia in the fasting an...
Tuberin, a tumor-suppressor protein produced by the tuberous sclerosis gene TSC2, downregulates the Rheb-mTOR-S6K pathwa...
...TSC2 gene on chromosome 16. The protein product of TSC1 is hamartin and that of TSC2 is tuberin. In cells, hamartin and ...
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