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AI-augmented discovery of autophagy regulators through mechanistic interpreta...

Tang(D),Xia(W),Zhang(C),Xue(Y),Peng(D) Autophagy 2026-08-21

...CTSL and FAM98A, are required for maintaining autophagy activity upon disulfiram (DSF) treatment. Silencing either CTSL ...

An AIE fluorescence sensor enables the discovery of Cathepsin L inhibitors in...

Liu(S),Zhang(W),Lin(J),Zhang(W),Li(M),Tian... Talanta 2026-08-10

...CTSL inhibitor screening. The sensor was constructed by linking an AIE fluorophore with a CTSL-specific substrate peptid...

Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine...

Mao(Z),Shen(C),Liang(S),Zhou(T),Li(J),Yang... Eur J Med Chem 2026-02-05

...CTSL), which contributes to inflammation, has been demonstrated as a promising therapeutic target for the treatment of A...

Novel treatment strategies for cardiovascular and pulmonary diseases: Insight...

Zhang(C),Xu(B),Yu(T),He(F),Hang(F),Qian(W) Medicine (Baltimore) 2026-01-02

...CTSL and CTSD; Bayesian colocalization yielded posterior probabilities (PPH4) of 0.0336 (CTSH-CTSD), 0.0477 (CTSH-CTSL),...

Interpreting the molecular and cellular landscape of PCOS through bulk transc...

Xu(K),Zhang(S),Guo(L),Liu(T),Li(Y),Zhang(Y... J Ovarian Res 2026-01-07

...CTSL-and yielded a diagnostic model with superior accuracy and specificity. Moreover, validation in clinical samples con...

A deep learning and large language hybrid workflow for omics interpretation.

Tang(D),Zhang(C),Zhang(W),Lu(F),Xiao(L),Hu... Nat Biomed Eng 2026-08-00

...CTSL and FAM98A, for enhancing autophagy upon treatment with disulfiram (DSF), an antitumour agent. Silencing these gene...

Effects of dietary nanoplastics exposure on muscle quality, immunity, antioxi...

Zhang(J),Fu(Q),Cheng(S),Ren(H),Mu(Y),Liu(J... Aquat Toxicol 2026-03-00

...ctsl and ctsb). In the digestive gland, NPs induced lipid accumulation (increased to 1.20-fold of the control level in t...

Modulation of inflammasome components in patients with heart failure using or...

Herrera-Martínez(AD),Hermán-Sánchez(N),G-G... Eur J Nutr 2026-02-03

...CTSL, IFI16, TLR8, PSXR7, CCR1, CHUCK, MAPK14, CDKN1B). We observed a significant downregulation of Nod-like receptors N...

Interferon-gamma-inducible protein 30 prevents IFN-γ-receptor 1 degradation t...

Mizuno(S),Mizuno(Y),Abe(K),Macy(AM),Chong(... Cell Commun Signal 2026-02-12

...CTSL), and modulating IFN-γ pathway signaling. Briefly, IFI30, PD-L1, MHC-II and CTSL levels are stimulated by IFN-γ in ...

Exploring the effects of tinzaparin and cisplatin on lung cancer cells in vitro.

Held(J),Schneider(MA),Martinez-Delgado(B),... Cancer Cell Int 2026-02-05

...CTSL (Cathepsin L) and HMOX1 (Heme Oxygenase 1) consistently altered by tinzaparin. CONCLUSION: Tinzaparin affects proli...

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