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Substance P and somatostatin neurons limit facial itch by recruiting distinct...

Wheeler(JJ),Williams(N),Vigneshwar(A),Lasc... Commun Biol 2026-05-02

...HRH1 and HRH3 are both involved in mediating mixed itch-and-pain sensations, the specific activity of Substance P (SP)- ...

Novel N-chloroacetyl-2-pyrazoline analogs with 2-naphthyl and ferrocenyl grou...

Veeragoni(D),Ghosh(H),Ansari(A),Bhattachar... Cancer Drug Resist None

...HRH1). In vivo antitumor efficacy was tested on HCT116 xenografts in NSG mice. Results: Compounds Clac10 and Clac12 sign...

Polyphyllin II inhibits thyroid cancer progression by targeting HRH1 and supp...

Sun(J),Liang(H),Zhang(Y),Ding(D),Xiang(Q),... Oncol Rep 2026-09-00

...HRH1) was identified as a key oncogenic target that is highly expressed in thyroid cancer and contributes to malignant p...

Tape Strip Transcriptomics Reveal Nemolizumab Effects on Pruritus, Hyperplasi...

Liu(D),Duca(ED),Delaleu(N),Lau(M),Pulsinel... Allergy 2026-09-04

...HRH1, KLK6/7/9) and genes involved in epidermal hyperplasia and ECM remodeling (e.g., COL1A1/12A1, IGFBP3). Inflammatory...

A HRH1-YAP1 feedback loop drives pancreatic cancer progression and predicts t...

Chen(J),Wen(J) Oncol Lett 2026-08-00

...HRH1 stabilizes and activates YAP1 signaling, while YAP1 knockdown downregulates HRH1 transcription, potentially through...

Induction of human pruriceptors from pluripotent stem cells via transcription...

Iriki(H),Hu(R),Li(X),Baljinnyam(E),Habich(... Stem Cell Reports 2026-08-11

...HRH1. The induction of this transcriptional program leads to functional maturation of iPruriceptors. Accordingly, iPruri...

MRGPRX2 Mediates Mast Cell-Induced Endometriosis Pain Through the Sensitizati...

Mao(X),Wang(J),Ding(S),Guo(X),Xu(X),Xu(P),... FASEB J 2025-07-15

...HRH1/TRPV1 signaling pathway and can serve as a novel therapeutic target for endometriosis pain.

SCOPE: Revealing Hidden Mechanisms in Phenotypic Screens Through Target and P...

Kapoor(A),Kelleher(K),Underhill(S),Jain(S)... bioRxiv 2025-07-14

...HRH1, which was validated by RNAi knockdown and pharmacological inhibition, implicating HRH1 as a potential therapeutic ...

Exploring the therapeutic potential of H1-antihistamines in endometriosis-A g...

Mantha(KB),Gajendran(MK) Front Med (Lausanne) 2025-00-00

...HRH1), we present a comprehensive discussion on the potential therapeutic value of H1-As in ES management due to their a...

Gut microbiota-derived histamine exacerbates psoriasis by promoting γδT17 cel...

Cheng(W),He(M),Jurat(E),Jin(L),Luo(S),Guan... Int Immunopharmacol 2025-12-03

...Hrh1 and activated the Wnt signaling pathway via pathway enrichment analysis. Further in vitro experiments confirmed tha...

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