Ye(W),Tang(G),Tang(J),Chang(L),Dan(Z),Xu(Y... J Adv Res 2026-02-11

...IL4I1). This impairment collapses the tryptophan metabolic axis, specifically reducing the production of the endogenous ...

Hu(Y),Jiang(Y),Du(Y),Zheng(Y),Xia(X) Biochim Biophys Acta Rev Ca... 2026-04-00

...IL4I1) has emerged as a key regulator of immune suppression and tumor growth. Through its enzymatic activity, IL4I1 meta...

Fhaikrue(I),Mahawan(T),Liu(H),Inoue(R),Ka(... Biochem Biophys Res Commun 2026-07-02

...Il4i1 double-knockout (DKO) mice to determine how two l-amino acid oxidases shape acute transcriptional responses to dex...

Aitken(RJ),Vazquez-Levin(MH),Hallak(JS),Te... Int J Mol Sci 2026-04-25

...IL4I1) and a calcium-dependent NADPH oxidase (NOX5). Spermatozoa tolerate the risks associated with ROS generation becau...

Neamah(AS) Naunyn Schmiedebergs Arch P... 2026-07-00

...IL4I1, VISTA, and TIGIT, which mediate immune escape through metabolic and signaling pathways distinct from the PD-1/PD-...

Zhou(S),Liang(R),Lu(P),Wang(W),Li(X),Yuan(... JHEP Rep 2026-06-00

...IL4I1+ macrophages as a critical therapeutic target for HCC. Our findings demonstrate that IL4I1+ macrophages exhibit a ...

Fiskin(E),Eraslan(G),Alora-Palli(MB),Jain(... Nat Commun 2026-02-25

...IL4I1+ fibroblasts, and clonally expanded IL13+IL22+IL26+ T cells connected by intercellular feedback loops predicted to...

Morgan(EW),Murray(IA),Coslo(DM),Patterson(... iScience 2026-02-20

...IL4I1) and serum tryptophan metabolites (indole-3-acetate, indole-3-lactate, indole-3-propionate, indole aldehyde, kynur...

Kim(JH),Kim(Y),Shin(Y),Park(I),Kwon(WS),Ki... Sci Rep 2026-05-19

...IL4I1), and vascular activation/dysfunction (OLR1, MMRN2), and downregulation of metastasis-related GAL3ST2. Notably, JX...

Yang(T),Lu(Y),Li(YQ),Bao(XH),Lu(HP),Xiong(WJ) Front Immunol None

...IL4I1+ M2-like macrophages. IL4I1 was highly expressed in HCC, predominantly within macrophages, and correlated with poo...