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Integrated metabolomic and transcriptomic analysis reveals novel plasma bioma...

Liu(D),Feng(Z),Meng(X),Li(Y),Zeng(Y),Li(Y)... Microbiol Spectr 2026-03-27

...IL4I1, EHHADH, IDO2, and ASMT) in peripheral blood mononuclear cells (PBMCs). External validation in independent cohorts...

Phosphorothioate antisense oligonucleotide induced innate immune activation i...

Pytte(J),Saldana(L),Zhang(W),Skourti-Stath... Nucleic Acids Res 2026-04-13

...IL4I1, accompanied by proportional changes in downstream metabolites. Complementary IDO1 knockdown and IL4I1 overexpress...

Machine learning-derived AS and AIS scores leverage BCAA metabolism and IL4I1...

Weng(KQ),Li(X),Chen(XB),Lin(JW),Liu(LJ),Ya... Front Cell Dev Biol None

...IL4I1 and branched-chain amino acid metabolism, along with the underlying causes of abnormal expression, using spatial t...

Dynamic changes in genes and metabolites during embryonic development of Jian...

Niu(Y),Qiu(Z),Zhou(Y),Li(S),Wu(Y),Zhao(A),... Poult Sci 2026-06-00

...IL4I1, MLKL) and lipid remodeling (PNPLA2, CCNB1). Furthermore, specific alterations in sulfur metabolism genes (CBS, CT...

The Tryptophan Paradox: From Microbiome-Mediated Homeostasis to Tumor-Driven ...

Cho(A),Wu(C),Theodoropoulos(G),Nagarajan(M... Int J Mol Sci 2026-05-12

...IL4I1), amino-acid transport, amino-acid stress sensing, and downstream aryl hydrocarbon receptor (AHR) signaling. In he...

Evolution of human IL4I1 preference for aromatic amino acids from a broad-spe...

Massari(M),Caroli(J),Malatesta(M),Marchese... Proc Natl Acad Sci U S A 2026-08-18

...IL4I1 and compared their properties to recombinant human IL4I1 purified from human cells. The tetrapodal ancestor displa...

Decoding IL4I1: The Core role of metabolism-driven immune regulation and new ...

Zhang(M),Dai(XJ),Huang(B),Zheng(S),Liu(HM)... Bioorg Chem 2026-04-00

Interleukin-4-induced protein 1 (IL4I1) is a secreted L-amino acid oxidase primarily produced by antigen-presenting cell...

Sirt6 promotes tumor growth and suppresses immune surveillance.

Wang(Y),Song(Y),Song(X),Zhang(N),Fang(K),C... Cancer Cell Int 2026-01-13

...IL4I1), which is known to control M2 polarization, was specifically detected in tumor tissues from UBCS039-treated mice ...

Conditional IL4I1 Inactivation Triggers Tumor-Associated Macrophage Reprogram...

Seradj(M),Kari(S),Llebaria-Fabrias(A),Roua... Cancer Immunol Res 2026-03-04

...IL4I1) expressed by TAMs in murine models of melanoma. We found that IL4I1 expression was increased in subsets of TAMs d...

Increased IL4I1 expression predicts poor survival and modulates the immune mi...

Huang(J),Chen(J),Yang(L),Zeng(Z),Lin(J),La... J Transl Med 2026-02-12

...IL4I1 on AML progression and immunoregulation. RESULTS: IL4I1 expression was significantly elevated in AML compared to n...

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