Yap(TA),Simpkins(F),Porte(M),Postel-Vinay(... Am Soc Clin Oncol Educ Book 2026-06-00

...MAT2A inhibitors in MTAP-deficient cancers, WRN inhibitors in microsatellite instablility-high tumors, as well as PKMYT1...

Bindl(D),Suga(H) J Am Chem Soc 2026-07-08

...MAT2A. The selected peptides contained structurally critical pcAgl motifs, inhibited the enzyme (best IC50 = 9 μM), and ...

Dela Cruz(FS),You(D),Feinberg(TY),Brosius(... Cancer Res 2026-07-02

...MAT2A inhibitor in MTAP-deficient PDXs. Universal model creation also allowed for experimental validation of therapeutic...

Lei(M),Zhu(W),Wang(C),Zhang(F),Li(M),Zhang... Sci China Life Sci 2026-05-00

...Mat2a) in macrophages leads to cell death by activating GSDME, resulting in suppression of tumor growth in vivo. Further...

Pedone da Rosa(V),Fontana(M),Richter Schmi... Biochem Pharmacol 2026-08-00

...MAT2A). Recent evidence further indicates that nucleoside transport dynamics, particularly via equilibrative nucleoside ...

Okada(N),Maruko(A),Oshima(K),Nishi(A),Koba... Int J Mol Sci 2026-03-30

...MAT2A, neuronal activity-triggered intron excision, and intron detention-mediated stemness/differentiation switching in ...

Gao(YJ),Zhou(Y),Li(YN),Yang(KY),Xia(SW),Hu... Toxicol Appl Pharmacol 2026-07-00

...MAT2A and AHCY. Supplementation with S-adenosylmethionine (SAM) partially reversed curcumol-associated changes in methio...

Bevilacqua(R),Gasperini(P),Cantore(T),Mace... NPJ Precis Oncol 2026-04-18

...MAT2A. Synergy between cytarabine and inhibitors of PRMT5 (MRTX1719) and MAT2A (AG-270) was mediated by a differential a...

Han(M),Lee(E),Shin(JE),Kwon(M),Hong(JY),Ki... Cancers (Basel) 2026-03-10

...MAT2A inhibition. The real-world prevalence and genomic context of MTAP deletion in diverse solid tumors remain incomple...

Gilaj(N),Wagner(AG),Li(T),Dedushi(D),Eskan... Anal Biochem 2026-07-00

...MAT2A inhibition, resulting in a synthetic lethal interaction. Consequently, MTAP has emerged as a target for enzymatic ...