Han(M),Lee(E),Shin(JE),Kwon(M),Hong(JY),Ki... Cancers (Basel) 2026-03-10

...MAT2A inhibition. The real-world prevalence and genomic context of MTAP deletion in diverse solid tumors remain incomple...

Bevilacqua(R),Gasperini(P),Cantore(T),Mace... NPJ Precis Oncol 2026-04-18

...MAT2A. Synergy between cytarabine and inhibitors of PRMT5 (MRTX1719) and MAT2A (AG-270) was mediated by a differential a...

Okada(N),Maruko(A),Oshima(K),Nishi(A),Koba... Int J Mol Sci 2026-03-30

...MAT2A, neuronal activity-triggered intron excision, and intron detention-mediated stemness/differentiation switching in ...

Gilaj(N),Wagner(AG),Li(T),Dedushi(D),Eskan... Anal Biochem 2026-07-00

...MAT2A inhibition, resulting in a synthetic lethal interaction. Consequently, MTAP has emerged as a target for enzymatic ...

Wang(BQ),Li(XC),Huo(Z),Zeng(K),Chen(S),Wan... Cancer Lett 2026-04-28

...MAT2A) is frequently overexpressed in tumors, linking nutrient availability to epigenetic reprogramming and tumor progre...

Yap(TA),Simpkins(F),Porte(M),Postel-Vinay(... Am Soc Clin Oncol Educ Book 2026-06-00

...MAT2A inhibitors in MTAP-deficient cancers, WRN inhibitors in microsatellite instablility-high tumors, as well as PKMYT1...

Vokes(NI),Symons(JL),Rhead(B),Hong(L),Shah... Clin Cancer Res 2026-07-27

...MAT2A inhibition. The clinicogenomic context and treatment outcomes of CMdel in NSCLC remain incompletely defined. We an...

Yuan(S),Xiao(B),Ni(S),Liu(W),Hou(M),Jiang(... J Transl Med 2026-08-03

...MAT2A) and S-adenosylmethionine levels and induces region-specific DNA hypermethylation of pro-inflammatory cytokine gen...

Lin(L),Xie(Z),Liu(J),Fan(Z),Shi(Z),Sun(Y),... J Med Chem 2026-08-13

Targeting methionine adenosyltransferase 2A (MAT2A) represents an attractive synthetic lethal approach for treating meth...

Hou(Y),Cheng(Y),Lin(Y),Sheng(H),Mao(X),Li(... Adv Healthc Mater 2026-08-00

...MAT2A) inhibitor PF9366 with the near-infrared (NIR)-absorbing dye IR808, followed by surface modification with DSPE-PEG...