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A potent, selective and cell-active allosteric inhibitor of protein arginine ...

Kaniskan(H Ümit),Szewczyk(Magdalena M),Yu(... Angew Chem Int Ed Engl 2016-01-12

...PRMT3 inhibitor would be a valuable tool for further investigating PRMT3 biology. Here we report the discovery of the fi...

New role of irisin in hepatocytes: The protective effect of hepatic steatosis...

Park(Min-Jung),Kim(Dong-Il),Choi(Joo-Hee),... Cell Signal 2016-03-29

...PRMT3). These findings suggested that irisin might have a beneficial role in the prevention of hepatic steatosis by alte...

PRMT3: new binding molecule to RhoGDI-α during mycophenolic acid-induced β-ce...

Huh(K H),Cho(Y),Kim(B S),Joo(D J),Kim(M S)... Transplant Proc 2015-01-02

...PRMT3) protein interacted with RhoGDI-α in INS-1E cells. PRMT3 gene expressions and its protein levels were significantl...

A novel BLAST-Based Relative Distance (BBRD) method can effectively group mem...

Wang(Yi-Chun),Wang(Jing-Doo),Chen(Chin-Han... Mol Phylogenet Evol 2015-06-18

...PRMT3, PRMT6, PRMT2 and PRMT4. The PRMT7/9 branch then connects with the type II PRMT5. Some non-vertebrates contain dif...

PRMT3 regulates hepatic lipogenesis through direct interaction with LXRα.

Kim(Dong-il),Park(Min-jung),Lim(Seul-ki),P... Diabetes 2015-03-11

...PRMT3 overexpression, but decreased by PRMT3 silencing and use of the PRMT3 knockout (KO) mouse embryonic fibroblast cel...

Arabidopsis protein arginine methyltransferase 3 is required for ribosome bio...

Hang(Runlai),Liu(Chunyan),Ahmad(Ayaz),Zhan... Proc Natl Acad Sci U S A 2015-04-14

...PRMT3 (AtPRMT3) is required for ribosome biogenesis by affecting pre-rRNA processing. Disruption of AtPRMT3 results in p...

Mutations in protein N-arginine methyltransferases are not the cause of FTLD-...

Ravenscroft(Thomas A),Baker(Matt C),Ruther... Neurobiol Aging 2014-01-17

...PRMT3, and PRMT8) and performed complete sequencing analysis and real-time polymerase chain reaction mRNA expression ana...

Profiling substrates of protein arginine N-methyltransferase 3 with S-adenosy...

Guo(Han),Wang(Rui),Zheng(Weihong),Chen(Yul... ACS Chem Biol 2014-10-15

...PRMT3 and identify suitable PRMT3 variants for BPPM. The M233G single point mutation transforms PRMT3 into a promiscuous...

Exploiting an allosteric binding site of PRMT3 yields potent and selective in...

Liu(Feng),Li(Fengling),Ma(Anqi),Dobrovetsk... J Med Chem 2013-05-14

...PRMT3 inhibitors with submicromolar potencies. An X-ray crystal structure of compound 14u in complex with PRMT3 confirme...

Evolutionarily conserved protein arginine methyltransferases in non-mammalian...

Wang(Yi-Chun),Li(Chuan) FEBS J 2013-03-28

...PRMT3, 4 and 7 in non-mammalian animals, the vertebrate-restricted distribution of PRMT8 and the special reptile/avian-d...

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