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Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activatio...

Nagai(Taku),Nakamuta(Shinichi),Kuroda(Keis... Neuron 2016-06-28

...Rasgrp2). We found that PKA phosphorylation of Rasgrp2 activated its guanine nucleotide-exchange activity on Rap1. Cocai...

Inherited disorders of platelet function: selected updates.

Nurden(A T),Nurden(P) J Thromb Haemost 2016-04-04

...RASGRP2, CalDAG-GEFI deficiency and integrin dysfunction; PRKACG, cyclic adenosine monophosphate-dependent protein kinas...

[Inherited thrombopathia in Simmental cattle].

Aebi(M),Wiedemar(N),Drögemüller(C),Zanolar... Schweiz Arch Tierheilkd 2016-07-08

...RASGRP2, initially reported in 2007, was present in all these cases and all available parents were heterozygous carriers...

Rasgrp2 regulates the permissiveness of NIH3T3 cells to a herpes simplex viru...

Xiao(W),Su(Y),Zhou(S),Yi(Ch),He(G),Liu(Y),... Acta Virol 2014-01-30

...Rasgrp2 which regulates the Ras signaling pathway. Rasgrp2 was found to bind directly to purified mtHSV as well as to mt...

Ras guanyl nucleotide releasing protein 2 affects cell viability and cell-mat...

Takino(Junichi),Nagamine(Kentaro),Hori(Tak... Cell Adh Migr 2014-02-06

...rasgrp2, which is a homolog of the human rasgrp2, plays a role in vasculogenesis and/or angiogenesis during early develo...

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and cause...

Canault(Matthias),Ghalloussi(Dorsaf),Grosd... J Exp Med 2014-09-04

...RASGRP2) gene coding for calcium- and DAG-regulated guanine exchange factor-1 (CalDAG-GEFI). Platelets from individuals ...

The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediat...

Zhu(Minghua),Fuller(Deirdre M),Zhang(Weigu... J Biol Chem 2012-05-01

...RasGRP2, and RasGRP3 play critical roles in T cells, platelets, and B cells, respectively. RasGRP4 is highly expressed i...

Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-depend...

Stadtmann(Anika),Brinkhaus(Laura),Mueller(... Eur J Immunol 2011-09-09

...Rasgrp2) and p38 MAPK as key signaling intermediates between PLCγ2 and Rap1a. Gαi-independent leukocyte adhesion to and ...

Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells...

Stone(James C) Genes Cancer 2011-11-10

...RasGRP2, through Rap, plays a role in controlling platelet adhesion, while RasGRP4 controls Ras activation in mast cells...

The kinetics of αIIbβ3 activation determines the size and stability of thromb...

Stolla(Moritz),Stefanini(Lucia),Roden(R Cl... Blood 2011-04-14

...RasGRP2) mediates the rapid but reversible activation of integrin αIIbβ3, while the adenosine diphosphate receptor P2Y12...

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