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IL-6 as a central driver of immune evasion in PDAC: from IDO-mediated toleran...

Wang(J),Tan(JSY),Shelat(VG),Lim(J) Front Immunol None

...SOCS3 silencing in tumour cells inverts the IL-6-IDO relationship seen in dendritic cells, generating an autocrine IDO-K...

Identification and functional validation of lipid droplet-associated prognost...

Yao(J),Liu(Z),Zhang(J),Long(X),Chao(C),Yua... Int J Clin Oncol 2026-09-00

...SOCS3 in immune cells. Functional assays confirmed SQLE promoted while SOCS3 inhibited adipogenesis. Modulating these ge...

Hepatocarcinogenesis in Metabolic Dysfunction-Associated Steatotic Liver Dise...

Solleiro-Villavicencio(H),Méndez-García(LA... Biomedicines 2026-05-12

...Socs3) showed minimal changes across stages, receptor subunits (Il10ra, Il10rb) and IL-10-responsive effectors (such as ...

NLRC5-Deficient Macrophages Promote a Tumor-Permissive Phenotype via AXL- and...

Haile(SA),Gatta(A),Colon(N),Philpott(DJ),K... FASEB J 2026-08-15

...Socs3) compared with WT cells. Importantly, Nlrc5-/-macrophages showed enhanced efferocytosis and reduced antigen presen...

The suppressor of cytokine signaling 3 regulates glioma stem cell maintenance...

Wang(J),Hou(G),Song(Z),Gao(K),Wang(H),Li(T... J Cell Commun Signal 2026-09-00

...SOCS3 stratification (SOCS3-High: n = 4; SOCS3-Low: n = 15). Differential gene analysis, pathway enrichment, and CellCha...

SOCS3 deficiency drives the primed to naive pluripotency transition by sustai...

Lu(R),Huang(S),Du(M),Yang(X),Liu(J),Lin(Z)... Front Genet None

...Socs3 was highly expressed in naive embryonic stem cells (ESCs) but minimally detected in EpiSCs. Socs3 deletion uncoupl...

Integrated Transcriptomic Analysis Unveils Hub Genes and Immune Dysregulation...

Wen(X),Zhang(J) J Inflamm Res None

...SOCS3, CXCL1, ICAM1, IL6, PTGS2, CCL2). LS showed increased activated mast cells, eosinophils, neutrophils, and monocyte...

Ketone Body β-Hydroxybutyrate Enhances Hypothalamic Leptin and Insulin Respon...

Xu(R),Takahashi(N),Kaneko(K) Nutrients 2026-02-10

...SOCS3 and TNFα expression and increased POMC expression. Furthermore, chronic ICV administration of β-HB from the onset ...

m6A-dependent translation of circPICALM encodes a novel metastasis-promoting ...

Li(H),Wang(S),Dai(F),Liu(H),Zhang(C),Liu(M... Mol Cancer 2026-03-04

...SOCS3 and STAT3 by directly binding to both proteins. This interference alleviates SOCS3-mediated suppression of JAK act...

Identification of key genes modules linking brain aging signatures and COVID-...

Xie(C),Zhao(Y),Wang(B),He(T),Chen(J),Wu(X) Virus Res 2026-04-00

...SOCS3, FKBP5, and HBB. Notably, SST expression was significantly reduced, whereas the other four genes showed marked upr...

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