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The critical role of the phosphorylation of STAT3 at Y705 in ALCL-associated ...

Lin(X),Korai(A),Nakazawa(Y),Tago(K),Funako... Cell Signal 2025-12-00

...SOCS3) as well as cell proliferation, tumor formation, and spleen, liver, and lymph node enlargement. These effects were...

ALKBH5 demethylates the m6A modification of SOCS3 in microglia/macrophages an...

Cai(L),Liang(Y),Li(X),Fu(R),Niu(X),Jin(Y),... Proc Natl Acad Sci U S A 2025-09-30

...SOCS3 was a downstream target of ALKBH5-mediated m6A demethylation. This demethylation stabilized Socs3 mRNA and enhance...

Human umbilical cord blood cells-secreted exosomal MFG-E8 regulates microglia...

Liu(Y),Zhao(M),Ling(M),Shen(M),Huang(F),Xu... Arch Biochem Biophys 2025-12-00

...SOCS3/STAT3 pathway. HUCB-ex and HUCB cells have equivalent therapeutic effects in HIBD rats. The treatment effectivenes...

The S1P/S1P1 Signaling Axis Plays Regulatory Functions in the Crosstalk Betwe...

Adir(O),Sagi-Assif(O),Ben-Menachem(S),Witz... Cancers (Basel) 2025-09-29

...SOCS3, TGFBR1, TGFBR2, and JunB, promoting a pro-inflammatory phenotype. It also reduced viability of both melanoma and ...

Case Report: Dual molecular diagnosis of gain-of-function STAT1 mutation and ...

Yaakoubi(R),Mekki(N),Ben Chehida(A),Benham... Front Immunol 2025-00-00

...SOCS3) expressions suggested a potential GOF effect. In silico analysis further predicted that the deletion disrupts mic...

Role of SOCS3 evaluated by immunohistochemical analysis in a cohort of patien...

Calarco(Alessandro),Pinto(Francesco),Pierc... Urologia 2016-04-22

...SOCS3- pt turned out to have a more aggressive disease compared with SOCS3+. In particular, also SOCS3+/- patients seeme...

LXR agonist regulates the carcinogenesis of PCa via the SOCS3 pathway.

Fu(Weihua),Yao(Jiwei),Huang(Yan),Li(Qianwe... Cell Physiol Biochem 2016-07-18

...SOCS3 pathway.,LNCaP cells were cultured and transfected with SOCS3 small-interfering RNA (SOCS3-siRNA) and control smal...

[Study of the mechanism underlying the effect of SOCS3 rs4969170 A/G polymorp...

Li(Fang),Zheng(Yingying),Shao(Cuiping),Fan... Zhonghua Gan Zang Bing Za Z... 2016-02-02

To study the mechanism underlying the effect of the SOCS3 rs4969170 A/G alleles on the occurrence of insulin resistance ...

TLR ligand induced IL-6 counter-regulates the anti-viral CD8(+) T cell respon...

Wu(Weimin),Dietze(Kirsten K),Gibbert(Kathr... Sci Rep 2016-03-28

...SOCS3 and downregulated STAT4 phosphorylation and T-bet. Moreover, combining TLR stimulation and IL-6 blockade during an...

Altered immunometabolism at the interface of increased endoplasmic reticulum ...

Lenin(Raji),Sankaramoorthy(Aravind),Mohan(... J Leukoc Biol 2016-01-06

...SOCS3 mRNA expression was reduced significantly (P < 0.05) in diabetes patients. mRNA expression of most of the ER stres...

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