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Efficacy and safety of IgG-pathway inhibitors in adult immune thrombocytopenia:…

Almasalma(M),Kandil(AH),Al-Qadi(MH),Maarouf(… Cytokine 2026-09-00

...SYK), neonatal Fc receptor (FcRn), and Bruton's tyrosine kinase (BTK) inhibitors, target the IgG pathway to improve plat...

HECT E3 ubiquitin ligase SMURF2 orchestrates FcεRI-dependent mast cell activati…

Liang(J),An(X),Yang(Y),Wang(N),Qiu(S),Yi(Z),… J Allergy Clin Immunol 2026-06-12

...Syk-mediated FcεRI signaling. SMURF2 is a critical positive regulator of mast cell activation and allergic responses by ...

Expression and mechanism exploration of lncRNA MALAT1 in children with IgA vasc…

Chang(S),Kan(Y),Zhang(T),Zhang(Q) Immunobiology 2026-07-00

...SYK axis. MALAT1 may be a biomarker of IgAVN, and the MALAT1/miR-142-3p/SYK axis may become a therapeutic target for IgA...

Megakaryocytes Internalize and Are Activated by Immune Complexes.

Puhm(F),Allaeys(I),Petito(E),Sang(Y),Tupin(F… Circ Res 2026-07-17

...Syk (spleen tyrosine kinase) signaling, and protein translation. A detailed analysis revealed that megakaryocyte-derived...

Evaluating Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Associated With …

Chen(H),Xu(L),Wang(Y),Zhuo(H),Zhou(H),Chen(X… Clin Ther 2026-06-30

...SYK) intersecting with SJS/TEN pathogenesis. Functional enrichment revealed significant involvement of T-cell receptor s...

Identification of senescence-related genes in Parkinson's disease reveals candi…

Wu(H),Liu(T),Cheng(X),Wei(J) Animal Model Exp Med 2026-06-30

...SYK and TYK2 proteins and alleviated pathological phenotypes in cellular models. Overall, this study demonstrates that D...

Astaxanthin inhibits platelet-mediated thrombosis via suppression of bidirectio…

Choi(H),Kim(YJ),Shin(HW),Jung(SM),Kim(K) Eur J Pharmacol 2026-07-15

...Syk), phospholipase C (PLC), phosphoinositide 3-kinase (PI3K), Akt, proline-rich tyrosine kinase 2 (Pyk2), and focal adh...

Metabolic rewiring overcomes physiological constraints in Sphingobium lignivora…

Mizuide(A),Kato(R),Fujita(M),Araki(T),Suzuki… Metab Eng 2026-09-00

...SYK-6 harbors extensive aromatic catabolic pathways, but its inability to utilize glucose and its methionine auxotrophy ...

Targeting SYK to alleviate MDSC-driven immunosuppression and augment anti-PD1 e…

Zeng(Z),Cao(X),Li(C),He(Y),Guo(H),Cao(X),Gon… Sci China Life Sci 2026-06-30

...SYK) activity in immune cells and tumor progression in human cancers. Utilizing a mouse model with a gain-of-function SY...

Toll-like receptor 4 signaling links cytoskeletal remodeling to lipid accumulat…

Wang(E),Hamezah(HS),Han(R),Tong(X) Inflamm Regen 2026-07-04

...SYK/Src, and integrins, engages small GTPases (Rac, Cdc42, Rho) and downstream effectors including cofilin and paxillin ...

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