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PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential the…

Alves(Maria M),Fuhler(Gwenny M),Queiroz(Karl… Sci Rep 2016-08-19

...TSC1/2. Further investigation showed that the effect of the TSC1/2 complex on PAK2 is mediated through RHEB, but is inde...

A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-abla…

Jones(Iwan),Hägglund(Anna-Carin),Törnqvist(G… Dis Model Mech 2016-09-12

...TSC1 or the TSC2 genes and consequent activation of the canonical mammalian target of rapamycin complex 1 signalling (mT...

miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastri…

Riquelme(Ismael),Tapia(Oscar),Leal(Pamela),S… Cell Oncol (Dordr) 2016-10-14

...TSC1, respectively.,Our expression analyses and in vitro functional assays suggest that miR-101-2, miR-125b-2 and miR-45...

Shared functional defect in IP₃R-mediated calcium signaling in diverse monogeni…

Schmunk(G),Boubion(B J),Smith(I F),Parker(I)… Transl Psychiatry 2016-07-11

...TSC1 and TSC2 syndromes-display depressed Ca(2+) release through inositol trisphosphate receptors (IP3Rs). This was appa...

Phase II Trial of Carboplatin, Everolimus, and Prednisone in Metastatic Castrat…

Vaishampayan(Ulka),Shevrin(Daniel),Stein(Mar… Urology 2016-05-10

...TSC1 gene mutations did not correlate with clinical outcome.,The addition of the mTOR inhibitor everolimus to carboplati...

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary …

Gui(Yao-Song),Wang(Lianmei),Tian(Xinlun),Li(… PLoS One 2016-05-26

...Tsc1 knock-down mice SPC-rtTA/TetO-Cre/Tsc1(fx/+) (STT). Doxycycline caused Tsc1 knock-down and consequently mTOR activa...

Intellectual ability in tuberous sclerosis complex correlates with predicted ef…

Wong(Ho Tin),McCartney(Deborah L),Lewis(Juli… J Med Genet 2016-09-12

...TSC1/TSC2 mutations were assessed using a range of IQ or developmental quotient (DQ) measures. Effects of mutations on T...

Hemispherectomy for Hemimegalencephaly Due to Tuberous Sclerosis and a Review o…

Cuddapah(Vishnu Anand),Thompson(Matthew),Blo… Pediatr Neurol 2016-08-03

...TSC1 mutation) and hemimegalencephaly who underwent a functional hemispherectomy for status epilepticus. No clinical sei...

Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent …

Kong(Bo),Cheng(Tao),Qian(Chengjia),Wu(Weiwei… Mol Cancer 2016-09-07

...Tsc1) deficiency, with or without deletion of p53 (Tsc1 (-/-) and Tsc1 (-/-) ; p53 (-/-) ). Activity of mTOR signaling w...

Hypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous scl…

Zhang(Longbo),Feliciano(David M),Huang(Tianx… Neurosci Lett 2016-06-17

...Tsc1 in newborn olfactory bulb (OB) neurons of conditional Tsc1 transgenic mice using neonatal electroporation. In addit...

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