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Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, bu…

Pearce(Andrew C),Wilde(Jonathan I),Doody(Gin… Blood 2003-03-10

...Vav2-, and Vav1/Vav2-deficient platelets. A weak inhibition of late-stage aggregation to CRP and thrombin was observed i...

Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide e…

Tamás(Péter),Solti(Zita),Bauer(Petra),Illés(… J Biol Chem 2003-04-30

...Vav2 is broadly expressed. Recently, Vav2 has been identified as a substrate for the epidermal growth factor (EGF) recep...

Vav1 couples T cell receptor to serum response factor-dependent transcription v…

Charvet(Celine),Auberger(Patrick),Tartare-De… J Biol Chem 2002-07-02

...Vav2 also enhances SRF through Rho GTPases, suggesting that Vav proteins are general regulators of SRF activation in lym...

Vav3 is regulated during the cell cycle and effects cell division.

Fujikawa(Keiko),Inoue(Yoshiro),Sakai(Masahar… Proc Natl Acad Sci U S A 2002-04-25

...Vav2 or Vav1. Here we report that the expression of Vav3 is regulated during the cell cycle. Strikingly, Vav3 was transi...

Critical but distinct roles for the pleckstrin homology and cysteine-rich domai…

Booden(Michelle A),Campbell(Sharon L),Der(Ch… Mol Cell Biol 2002-04-22

...Vav2 membrane localization. Finally, we found that phosphoinositol 3-kinase activation synergistically enhanced Vav2 tra...

Structural and biophysical insights into the role of the insert region in Rac1 …

Thapar(Roopa),Karnoub(Antoine E),Campbell(Sh… Biochemistry 2002-04-19

...Vav2)-mediated exchange rate is observed. In addition, deletion of the insert does not change the K(D) for the interacti...

Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and …

Price(Marianne O),Atkinson(Simon J),Knaus(Ul… J Biol Chem 2002-06-24

...Vav2 or Tiam1 derivatives. These data suggest that Rac can play a dual role in NADPH oxidase activation, both by directl...

Small interfering RNAs as a tool to assign Rho GTPase exchange-factor function …

Gampel(Alexandra),Mellor(Harry) Biochem J 2002-10-17

...Vav2 exchange factor. These studies demonstrate that siRNAs are an ideal research tool for the assignment of Rho GEF fun...

Regulation of Ras and Rho small G proteins by SHP-2.

Kodama(A),Matozaki(T),Shinohara(M),Fukuhara(… Genes Cells 2002-02-28

...Vav2 also reversed the SHP-2-DA-induced morphological phenotypes.,These results indicate that SHP-2 plays a crucial role...

Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Ra…

Bourguignon(L Y),Zhu(H),Zhou(B),Diedrich(F),… J Biol Chem 2002-01-31

...Vav2 and in vitro binding assays, we have detected a specific binding interaction between the SH3-SH2-SH3 domain of Vav2...

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