...TSC2 gene products are hypothesized to function as growth regulators by modulating the activities of small GTPase molecu...
...Tsc2 is the rate-limiting step for renal carcinogenesis in the Eker rat model. Although inactivation of Tsc2 results in ...
...Tsc2) gene in a 5'-to-5' orientation by sequence analysis and was assigned to chromosome 17A3 by in situ hybridization.
...Tsc2 locus has been described in an animal model, the Eker rat. We report that the homozygous state of this mutation (Ts...
...TSC2 in TSC2-negative cells. High ectopic levels of p27 have cell cycle inhibitory effects in TSC2-positive cells but no...
...TSC2). The recently cloned TSC1 gene has 23 exons spanning some 40 kb of genomic DNA with an 8.6 kb transcript. We now r...
...TSC2) gene on chromosome 16p13.3 in a 5'-to-5' orientation. Transcription initiation sites of both NTHL1 and TSC2 genes ...
...TSC2 is yet to be determined. We have examined the entire coding sequence of the TSC2 gene in 20 familial and 20 sporadi...
...TSC2 gene has been found to be increased in gangliogliomas, a lesion which is associated with disturbed neuro-glial cell...
...Tsc2) causes renal cell carcinomas (RCs) with a complete penetrance in all heterozygotes. Tsc2 mutations have also been ...
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