...TSC2) gene. This will be the first step toward the positional cloning and identification of the predisposing Eker mutati...
...TSC2 as the chromosome 16 TSC gene. The 5.5 kb TSC2 transcript is widely expressed, and its protein product, tuberin, ha...
...TSC2 locus in a genomic region that is reiterated more proximally on 16p. The duplicate area encodes three transcripts s...
...TSC2 on chromosome 16 close to D16S291. There was no definite support for a third locus although in many families this c...
...TSC2) maps in the region of the anonymous DNA marker Lam L7 and the dopamine D2 receptor gene at 11q23.
...Tsc2, 87TRH-5-Tsc3) developed from the induced tumour, proved to bear CMV-spcific cytoplasmic and surface antigens. Demo...
...TSC2. Thus, Tnfaip8l1/Oxi-β competes with TSC2 to bind FBXW5, increasing TSC2 stability by preventing its ubiquitination...
...TSC2 tumor suppressor complex, which in turn inhibits Rheb, thereby reducing mTORC1 activity and consequently suppressin...
...TSC2, the heterodimer protein inhibitor of mTORC1 signaling. The underlying mechanism of bone lesions in TSC is unclear....
...TSC2-positive and TSC2-negative mouse embryonic fibroblasts (MEF), 323-TSC2-positive and 323-TSC2-null MEF and Eker rat ...
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