Identification of NF1, TSC2 and TSC1 genes has enabled us to focus on their function and regulation. Evidence suggests t...
...TSC2 (chromosome 16p13) genes. TSC2 LOH was detected in seven (54%) of the angiomyolipomas. We also found TSC2 LOH in fo...
...TSC2), the large size of the TSC2 gene, and the variety of mutations. More than half of the mutations that we identified...
...TSC2 gene, in cerebral, renal and cardiac tissues obtained from patients with tuberous sclerosis and from control patien...
...TSC2). Analysis of the 5' flanking region of the hSSTR5 gene has revealed consensus sequences for a number of transcript...
...TSC2) for both loci have recently been cloned, their function remains an enigma. Data presented here demonstrates that T...
...TSC2 gene that predisposes them to renal carcinoma, whereas additional factors influence tumor promotion/progression in ...
...TSC2. We suggest that an additive or synergistic effect between PKD1 and TSC2 may cause this renal phenotype. A contiguo...
...TSC2-containing region on 16p in one case, and on 3p in two cases, showing that multiple genetic alterations are taking ...
...TSC2) predisposing gene in the Eker rat model. In this study, we searched for mutations of the Tsc2 gene in chemically i...
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