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TP53 BRCA1 CRISPR single-cell cancer

Okamoto(T),Momose(S),Hino(O) Int J Oncol 2001-02-15

...TSC2 gene mutant (Eker) rat RCs are an example of a Mendelian dominantly inherited predisposition to a specific cancer i...

Okimoto(K),Kouchi(M),Kikawa(E),Toyosawa(K),K… Jpn J Cancer Res 2001-02-01

...Tsc2, VHL, and c-Met genes. Thus, the Nihon rat should be a valuable experimental model for understanding renal carcinog...

Mayer(K),Ballhausen(W),Leistner(W),Rott(H) Biochim Biophys Acta 2001-01-11

Disease causing aberrations in both tuberous sclerosis predisposing genes, TSC1 and TSC2, comprise nearly every type of ...

Parry(L),Maynard(J H),Patel(A),Hodges(A K),v… Hum Genet 2001-01-04

Reduced expression of the TSC2 tumour suppressor gene product, tuberin, has been reported in sporadic astrocytomas, sugg...

Kutsche(K),Glauner(E),Knauf(S),Pomarino(A),S… Cytogenet Cell Genet 2001-03-29

...TSC2, are known to be responsible for different inherited diseases presenting with multiple hamartomas, a benign tumor r...

Brown(J),Horsley(S W),Jung(C),Saracoglu(K),J… Eur J Hum Genet 2001-02-22

...TSC2. This and further FISH deletion mapping studies revealed a submicroscopic deletion encompassing the entire TSC2 gen...

Benvenuto(G),Li(S),Brown(S J),Braverman(R),V… Oncogene 2001-03-22

...TSC2) gene, tuberin. As overexpression of tuberin inhibits cell growth, and hamartin is known to bind tuberin, these res...

Roberts(P S),Jozwiak(S),Kwiatkowski(D J),Dab… J Biochem Biophys Methods 2001-05-21

...TSC2) and together account for all cases [1,2]. Here we report our methods for DHPLC analysis of the TSC1 gene and demon...

Fleming(N),Maynard(J),Tzitzis(L),Sampson(J R… J Biochem Biophys Methods 2001-05-21

...TSC2 gene. In a blind analysis, 15/15 previously characterised mutations were successfully identified using seven overla...

Catania(M G),Johnson(M W),Liau(L M),Kremen(T… J Neurosci Res 2001-04-26

...TSC2, that encodes tuberin. We have examined hamartin expression in a diverse range of human and rat cell lines and prim...

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