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TP53 BRCA1 CRISPR single-cell cancer

Yamashita(Y),Yokoyama(M),Kobayashi(E),Takai(… Biochem Biophys Res Commun 2000-09-21

The Eker rat develops hereditary renal carcinomas (RCs) due to two hit mutations of the tumor suppressor gene, Tsc2. We ...

Wolf(D C),Goldsworthy(T L),Janszen(D B),Hard… Carcinogenesis 2000-08-23

Induced cell proliferation is important in the mode of action of many non-genotoxic renal carcinogens. Since Tsc2 mutant...

Nellist(M),van Slegtenhorst(M A),Goedbloed(M… J Biol Chem 2000-01-13

...TSC2 gene are responsible for the disease. The TSC1 gene encodes hamartin, a 130-kDa protein without significant homolog...

Lacronique(J),Urban(T) Rev Pneumol Clin 2000-01-27

...TSC2 (16p 13.3). The TSC2 locus could be implicated in the pathogenesis of pulmonary LAM. LAM and BTS have similar clini...

Lininger(R A),Zhuang(Z),Man(Y),Park(W S),Emm… Mod Pathol 2000-01-10

...TSC2/PKD1 gene region), 17p13 (TP53), 17q13 (NM23), and 22q12 (D22S683).,Among informative in situ and invasive apocrine...

Yamashita(Y),Ono(J),Okada(S),Wataya-Kaneda(M… Am J Med Genet 2000-03-15

...TSC2 genes, using single-strand conformational polymorphism analysis and direct sequencing. Four possible pathogenic mut...

Astrinidis(A),Khare(L),Carsillo(T),Smolarek(… J Med Genet 2000-02-18

...TSC2. Twelve of the patients had known renal angiomyolipomas. No TSC2 mutations were detected. We did find three silent ...

Murthy(V),Haddad(L A),Smith(N),Pinney(D),Tys… Am J Physiol Renal Physiol 2000-06-12

...TSC2 genes, coding hamartin and tuberin, respectively. Immunofluorescence analysis of tuberin and hamartin performed her...

Carsillo(T),Astrinidis(A),Henske(E P) Proc Natl Acad Sci U S A 2000-06-30

...TSC2 loss of heterozygosity in 7 of 13 (54%) of angiomyolipomas from sporadic LAM patients, suggesting that LAM and TSC ...

Pasumarthi(K B),Nakajima(H),Nakajima(H O),Ji… Circ Res 2000-06-20

...TSC2-deficient cells. Surprisingly, targeted expression of the most potent TSC2 cDNA to the heart did not perturb cardia...

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