...TSC2 locus in a genomic region that is reiterated more proximally on 16p. The duplicate area encodes three transcripts s...
...TSC2) gene. This will be the first step toward the positional cloning and identification of the predisposing Eker mutati...
...TSC2 as the chromosome 16 TSC gene. The 5.5 kb TSC2 transcript is widely expressed, and its protein product, tuberin, ha...
...TSC2). We have found no indication for a third locus for TSC, linked or unlinked to either of these chromosomal regions....
...TSC2) maps in the region of the anonymous DNA marker Lam L7 and the dopamine D2 receptor gene at 11q23.
...Tsc2, 87TRH-5-Tsc3) developed from the induced tumour, proved to bear CMV-spcific cytoplasmic and surface antigens. Demo...
...TSC2 tumor suppressor complex, which in turn inhibits Rheb, thereby reducing mTORC1 activity and consequently suppressin...
...TSC2. Thus, Tnfaip8l1/Oxi-β competes with TSC2 to bind FBXW5, increasing TSC2 stability by preventing its ubiquitination...
...Tsc2 complex and Rheb act as upstream players of TORC1 in fission yeast. We have recently demonstrated that TORC1, but n...
...TSC2, a major mTOR inhibitory protein, or PTEN, a phosphatase that attenuates the PI3K/AKT/mTOR pathway. Only TSC2-delet...
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