...Tsc2 tumor suppressor gene and provides a valuable experimental model to characterize the function of the Tsc2 gene prod...
Functional inactivation of tuberous sclerosis 2 gene (Tsc2) leads to renal carcinogenesis in the hereditary renal carcin...
The tuberous sclerosis gene products Tsc1 and Tsc2 behave as tumor suppressors by restricting cell growth, a function co...
...tsc2, mapped to the distal tip of the short arm of chromosome 2B. This gene was responsible for the effects of a major Q...
...TSC2 GAP activity. We demonstrated a novel catalytic mechanism of the TSC2 GAP and Rheb that TSC2 uses a catalytic "aspa...
...TSC2 tumor suppressor complex. Mutations in LKB1 cause Peutz-Jeghers syndrome (PJS), and mutations in either TSC1 or TSC...
Germline mutations in LKB1, TSC2, or PTEN tumor suppressor genes result in hamartomatous syndromes with shared tumor bio...
...TSC2 (tuberin) gene mutations, in addition to thickening of interstitial tissues, loss of alveoli, and the development o...
...TSC2, which encode hamartin and tuberin, respectively. Tuberin and hamartin form a complex that inhibits signaling by th...
...TSC2-) lose the phenyl groups first, destabilizing the high oxidation state of the metal and leading to Pb(II) complexes...
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