To find the mutation and polymorphism spectrum of TSC1 and TSC2 genes in patients affected with tuberous sclerosis compl...
...TSC2 in which cardiac rhabdomyomas are seen in approximately 60% of patients. These lesions have an unusual natural hist...
...TSC2 phosphorylation at Thr1462 and deactivated translational regulators. In contrast, HFS acutely increased phosphoryla...
...TSC2 and the mammalian target of rapamycin to stimulate cell growth. We report here the three-dimensional structures of ...
...TSC2 (tuberous sclerosis complex 2), a negative regulator of mTOR activity. TSC2 was phosphorylated only weakly at Thr14...
...TSC2, as negative regulators for TOR signaling. Furthermore, the discovery that the small GTPase Rheb is a direct downst...
...TSC2 genes. Tsc1+/- and Tsc2+/- mice frequently develop liver hemangioma. We found that the Tsc mouse liver hemangioma a...
...TSC2 complex and Rheb) has provided new insights into the mechanism by which TOR integrates its various inputs. A recent...
...TSC2, thus inhibiting cell growth during times of stress. AMPK is also a target for adipokines that regulate energy bala...
...TSC2), and autosomal dominant polycystic kidney disease (ADPKD). ARPKD is a rare disease, related to PKHD1 gene, located...
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