...TSC2 gene. Previous studies have shown that deletion of the TSC1 or TSC2 ortholog in Schizosaccharomyces pombe results i...
...TSC2 genes and characterized by the development of benign hamartomatous growths in multiple organ systems. We have inact...
...TSC2. By using quantitative phosphorylation profiling in conjunction with pharmacological kinase inhibitors we uncovered...
...TSC2 complex, both of which respond to energy deprivation in cells. In addition, glucose starvation not only signals to ...
...TSC2. Pathologically, tuberous sclerosis complex is characterized by abnormal cellular differentiation and proliferation...
...TSC2), which is a negative regulator of mTOR. Here we establish an additional pathway by which Akt inhibits TSC2 and act...
...Tsc2 loss of heterozygosity (LOH) in both Tsc2+/- and Pten+/-Tsc2+/- mice. These findings demonstrate that inactivation ...
The PTEN and TSC2 tumor suppressors inhibit mammalian target of rapamycin (mTOR) signaling and are defective in distinct...
...TSC2, and a number of proto-oncogenes including PI3K, Akt, and eIF4E, and mTOR signaling is constitutively activated in ...
...TSC2 tumour suppressor gene. The TSC1 and TSC2 gene products, TSC1 and TSC2, form a protein complex that integrates inpu...
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