...TSC2, in a signaling pathway involving the mammalian target of rapamycin (mTOR) kinase. We performed immunohistochemical...
...TSC2) functions as a Rheb GTPase activator and inhibits TOR signaling in vivo.,Here, we show that Rheb binds to the TOR ...
...TSC2. Erk-dependent phosphorylation leads to TSC1-TSC2 dissociation and markedly impairs TSC2 ability to inhibit mTOR si...
...TSC2 (tuberin). The LKB1-->AMPK-->TSC2 pathway negatively regulates the target of rapamycin (TOR), and this appears to b...
...TSC2 tumour suppressor gene. Hamartin and tuberin, the TSC1 and TSC2 gene products, interact and the tuberin-hamartin co...
...tsc2+, the S. pombe homologs for the mammalian TSC1 and TSC2, are also defective in leucine uptake. TSC1 and TSC2 may an...
...TSC2, encoding tuberin are responsible for TSC. Since their identification 1997 and 1993 respectively, a variety of diff...
...TSC2 encoding tuberin are tumor suppressor genes responsible for the autosomal dominantly inherited disease tuberous scl...
...TSC2. Loss of function of the TSC1-TSC2 complex, which acts as a Rheb GAP, yields constitutive, unrestrained signaling f...
...TSC2 in muscle. The ability of LPS to blunt the anabolic effects of Leu could not be attributed to differences in the pl...
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