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Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in…

Gan(Boyi),Melkoumian(Zara K),Wu(Xiaoyang),Gu… J Cell Biol 2005-10-28

...TSC2 complex through FIP200 binding to TSC1. We found that association of FIP200 with the TSC1-TSC2 complex correlated w...

The cellular response to ectopic overexpression of the tuberous sclerosis genes…

Hengstschläger(Markus),Rosner(Margit),Founto… Int J Oncol 2005-09-12

The genes, TSC1 on chromosome 9q34, encoding hamartin, and TSC2 on chromosome 16p13.3, encoding tuberin, are responsible...

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 k…

Byfield(Maya P),Murray(James T),Backer(Jonat… J Biol Chem 2005-11-28

...TSC2 in insulin-stimulated cells. However, hVps34 is inhibited by amino acid or glucose starvation, suggesting that it l...

Distinct allelic variants of TSC1 and TSC2 in epilepsy-associated cortical malf…

Majores(Michael),Blümcke(Ingmar),Urbach(Hors… J Neuropathol Exp Neurol 2005-08-11

...TSC2 genes, suggest common pathogenetic mechanisms. Previous studies revealed different alterations of TSC1 and TSC2 in ...

Aberrant beta-catenin signaling in tuberous sclerosis.

Mak(Baldwin C),Kenerson(Heidi L),Aicher(Laur… Am J Pathol 2005-08-25

...TSC2 missense mutants to inhibit Wnt signaling. Further, the interaction between TSC1/TSC2 and components of the beta-ca...

Interferon-gamma-Jak-Stat signaling in pulmonary lymphangioleiomyomatosis and r…

El-Hashemite(Nisreen),Kwiatkowski(David J) Am J Respir Cell Mol Biol 2005-11-01

...TSC2 genes play a critical role in their pathogenesis. Here we report a marked decrease in interferon (IFN)-gamma expres...

Regulation of mTOR and cell growth in response to energy stress by REDD1.

Sofer(Avi),Lei(Kui),Johannessen(Cory M),Elli… Mol Cell Biol 2005-09-01

The tuberous sclerosis tumor suppressors TSC1 and TSC2 regulate the mTOR pathway to control translation and cell growth ...

Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in…

Jiang(Wen G),Sampson(Julian),Martin(Tracey A… Eur J Cancer 2005-09-12

...TSC2 promoter. In breast tissues, however, a very small number of samples were found to have methylation of the TSC2 pro...

Farnesyltransferase inhibitors reverse altered growth and distribution of actin…

Gau(Chia-Ling),Kato-Stankiewicz(Juran),Jiang… Mol Cancer Ther 2005-09-26

...Tsc2 complex. Both Tsc1(-/-) and Tsc2(-/-) mouse embryonic fibroblasts exhibit constitutive activation of S6K and grow i...

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

Johannessen(Cory M),Reczek(Elizabeth E),Jame… Proc Natl Acad Sci U S A 2005-08-16

...TSC2-encoded protein tuberin by AKT. Importantly, tumor cell lines derived from NF1 patients, and a genetically engineer...

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