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Elevated plasma free fatty acids decrease basal protein synthesis, but not the …

Lang(Charles H) Am J Physiol Endocrinol Metab 2006-09-26

...TSC2, S6K1, or the ribosomal protein S6 under basal conditions. In control rats, oral leucine increased muscle protein s...

Comparative genomic hybridization study of perivascular epithelioid cell tumor:…

Pan(Chin-Chen),Jong(Yiin-Jeng),Chai(Chee-Yin… Hum Pathol 2006-06-01

...TSC2 gene is located indicates the oncogenetic relationship of PEComas with angiomyolipoma as a TSC2-linked neoplasm. Fr...

Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kin…

Connolly(Eileen),Braunstein(Steve),Formenti(… Mol Cell Biol 2006-06-09

...TSC2) protein fails to function. Gene silencing of 4E-BP1 and eEF2 kinase or TSC2 confers resistance to hypoxia inhibiti...

AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 ki…

Riemenschneider(Markus J),Betensky(Rebecca A… Cancer Res 2006-07-27

...TSC2, p-mTOR, p-4E-BP1, p-S6K, p-S6, and p-STAT3 were found in regions defined by elevated AKT activation. However, only...

Novel mutation in the TSC2 gene associated with prenatally diagnosed cardiac rh…

Chen(Chih-Ping),Su(Yi-Ning),Hung(Chia-Cheng)… J Formos Med Assoc 2006-08-23

...TSC2. We report a 28-year-old, gravida 5, para 2, woman with an uncomplicated pregnancy until prenatal ultrasound at 34 ...

Clinical and genotype studies of cardiac tumors in 154 patients with tuberous s…

Jóźwiak(Sergiusz),Kotulska(Katarzyna),Kasprz… Pediatrics 2006-10-11

...TSC2 genotypes.,Patients (154) with tuberous sclerosis complex were evaluated, including clinical assessment, electrocar...

The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kap…

Sodhi(Akrit),Chaisuparat(Risa),Hu(Jiadi),Ram… Cancer Cell 2006-09-29

...TSC2) phosphorylation by vGPCR, promoting the activation of mTOR through both direct and paracrine mechanisms. Pharmacol...

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen…

Schieke(Stefan M),Phillips(Darci),McCoy(J Ph… J Biol Chem 2006-10-31

...TSC2, p70 S6 kinase (S6K1), raptor, or rictor demonstrates that mTOR regulates mitochondrial activity independently of i...

Combination of a rapamycin analog (CCI-779) and interferon-gamma is more effect…

Lee(Laifong),Sudentas(Paul),Dabora(Sandra L) Genes Chromosomes Cancer 2006-10-03

...TSC2 gene result in constitutive activation of the highly conserved mTOR signal transduction pathway, which regulates ce...

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of A…

Zhang(Hui H),Lipovsky(Alex I),Dibble(Christi… Mol Cell 2006-11-30

...TSC2. In these settings, GSK3 phosphorylation is sensitive to mTORC1 inhibition by rapamycin or amino acid withdrawal, a...

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