...TSC2) and characterized by the development of tumor-like growths (angiofibromas) in a variety of tissues and organs, par...
...TSC2). Conversely, energy depletion reduces Rheb-GTP charging through the ability of the adenosine monophosphate-activat...
...TSC2/Rheb/Raptor-mTOR/S6K1 cell growth cassette has recently been shown to regulate cell autonomous insulin and insulin-...
...TSC2 gene or even the site of tubers in the brain.
...TSC2 (tuberous sclerosis complex), a protein with which RTP801 interacts to block mTOR activation. Our findings thus sug...
...TSC2 and leads to inhibition of the mTOR signaling. The hTSC1-mTSC2 hetero-complex and its downstream components remain ...
...TSC2, a potential upstream regulator of mTOR, was not significantly altered during meal feeding. Phosphorylation of prot...
...TSC2 tumor suppressor genes. The genes follow the two-hit model for tumorigenesis, with germline mutations inactivating ...
...TSC2 genes have been reported.,Mutational analysis of TSC1 and TSC2 genes was performed in 84 Taiwanese TSC families usi...
...TSC2 to inhibit mTOR activity. Surprisingly, the phosphorylation of TSC2 by GSK3 is markedly suppressed by Wnt signaling...
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