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Molecular profiling of soft tissue sarcomas using next-generation sequencing:...

Jour(George),Scarborough(John D),Jones(Rob... Hum Pathol 2014-09-22

...PDGFRB, EPHA5, KDM6A, NF1, and FLT4 genes, were also identified. NGS is useful in identifying targetable mutations in so...

Patients with myeloid malignancies bearing PDGFRB fusion genes achieve durabl...

Cheah(Chan Y),Burbury(Kate),Apperley(Jane ... Blood 2014-08-14

Myeloid neoplasms and eosinophilia with rearrangements of PDGFRB are uncommon Philadelphia-negative myeloproliferative n...

Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and rep...

Lakhe-Reddy(Sujata),Li(Vincent),Arnold(Tho... Am J Physiol Renal Physiol 2014-09-30

...PDGFRB (flox/-) mice compared with Cre(+/-) PDGFRB (flox/+) control mice. To establish the mechanism, in vitro experimen...

ALK gene aberrations and the JUN/JUNB/PDGFR axis in metastatic NSCLC.

Berghoff(Anna Sophie),Birner(Peter),Streub... APMIS 2014-11-21

...PDGFRB) via JUN and transcription factor Jun B (JUNB) in ALCL. PDGFRB inhibition has been identified as therapy option f...

Medial prefrontal cortex: genes linked to bipolar disorder and schizophrenia ...

Eisinger(Brian E),Driessen(Terri M),Zhao(C... Front Behav Neurosci 2014-04-25

...Pdgfrb), and nuclear receptor subfamily 1, group D, member 1 (Nr1d1). RT-qPCR confirmed these gene changes as well as FM...

Transcriptome profiling of malignant transformed rat hepatic stem-like cells ...

Yang(L),Ji(J),Chen(Z),Wang(H),Li(J) Neoplasma 2014-03-26

...Pdgfrb and Tmsb4x. These findings would contribute to a growing knowledgebase on the mechanism of aflatoxin-induced hepa...

Targeting signaling pathways in acute lymphoblastic leukemia: new insights.

Harrison(Christine J) Hematology Am Soc Hematol E... 2014-12-09

...PDGFRB may benefit from treatment with tyrosine kinase inhibitors. Other aberrations, for example, CRLF2 overexpression ...

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

Roberts(Kathryn G),Li(Yongjin),Payne-Turne... N Engl J Med 2014-09-16

...PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common. Expression of ABL1,...

VEGF-dependent continuous angiogenesis in the median eminence of adult mice.

Morita(S),Ukai(S),Miyata(S) Eur J Neurosci 2013-11-04

...PDGFRB), and delta-like ligand 4 was observed at pericytes of adults, although the expression of these angiogenesis-asso...

Casitas B-lineage lymphoma mutants activate AKT to induce transformation in c...

Polzer(Harald),Janke(Hanna),Schmid(Diana),... Exp Hematol 2013-05-20

...PDGFRB, KIT, and FLT3), but not with non-class III RTKs or cytokine receptors, to induce IL-3-independent growth of Ba/F...

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