...TSC2) phosphorylation by vGPCR, promoting the activation of mTOR through both direct and paracrine mechanisms. Pharmacol...
...TSC2 genotypes.,Patients (154) with tuberous sclerosis complex were evaluated, including clinical assessment, electrocar...
...TSC2 tumor suppressor genes. The genes follow the two-hit model for tumorigenesis, with germline mutations inactivating ...
...TSC2 genes have been reported.,Mutational analysis of TSC1 and TSC2 genes was performed in 84 Taiwanese TSC families usi...
...TSC2) and characterized by the development of tumor-like growths (angiofibromas) in a variety of tissues and organs, par...
...TSC2 and GSK3, and the TORC1 effectors, S6K and 4E-BP1, were unaffected. Our findings reveal that the SIN1-rictor-mTOR f...
...TSC2 to inhibit mTOR activity. Surprisingly, the phosphorylation of TSC2 by GSK3 is markedly suppressed by Wnt signaling...
Mutation in the TSC2 tumor suppressor causes tuberous sclerosis complex, a disease characterized by hamartoma formation ...
...TSC2 expression in TSC2(-/-) MEFs rescued survival in an NF-kappaB activity-dependent manner. Furthermore, in TSC2(-/-) ...
...TSC2, a potential upstream regulator of mTOR, was not significantly altered during meal feeding. Phosphorylation of prot...
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