...TSC2) as a key player in signal transduction pathways involved in the development of cancer. Importantly, the discovery ...
...TSC2) and their gene products (hamartin and tuberin, respectively), revealed that they function together as a complex. H...
...Tsc2-RGH and Tsc2-DRG in Eker rats completely suppressed renal carcinogenesis and rescued homozygous (Tsc2(Ek/Ek)) mutan...
...TSC2 is regulated by growth factors, nutrients, and energy; thus, TSC1/TSC2 serves as a signaling module for protein tra...
...TSC2 genes result in mTOR-signaling activity. Here, we addressed whether Pi3K-pathway activation differentiates balloon ...
...TSC2, NF-1, vHL, p53, bcl-2, bax, VEGF, IGF, PDGF, EGFR, and mTOR. Recently, there has been interest in developing molec...
...TSC2, and SDF2. Gene expression levels paralleled chromosomal changes only in 56% of the genes, suggesting that, as a ge...
...TSC2. About 80% of affected patients have a new mutation, and the remaining 20% have inherited a TSC gene mutation from ...
...TSC2 tumor suppressors. Insulin stimulates the phosphorylation of S6K1, an mTORC1 substrate, but it is not known how mTO...
...TSC2 dephosphorylation, and inhibits signaling by mammalian target of the rapamycin (mTOR). These findings demonstrate t...
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