...Tsc2 knockout we have generated a conditional allele of the Tsc2 gene by homologous recombination in mouse ES cells. The...
...tsc2 gene product-related genes, and an inhibitor of differentiation protein 2 (Id2) were differentially temperature-inf...
...TSC2-/- cells indicate that TSC2 and IRS-1 cooperate with, but are dispensable for, A-443654-mediated Akt phosphorylatio...
...TSC2). However, in recent studies the physiological requirement of Akt phosphorylation of TSC2 for mTOR activation has b...
...TSC2 on 16p13.3. TSC complex may affect the skin, central nervous system, kidneys, heart, eyes, blood vessels, lungs, bo...
...TSC2 genes and the demonstration of their involvement in sporadic (non-TSC) LAM. This was followed by rapid delineation ...
...TSC2. Protein products of these genes, hamartin and tuberin, respectively, have been shown to participate in the mTOR pa...
...TSC2 mutation) have been identified. Hormonal influences, especially associated with more severe liver disease in female...
...TSC2, PTEN, and IGF-BP3, each of which negatively regulates the IGF-1-AKT-mTOR pathways after stress. These gene product...
...TSC2 or GSK3beta, requires mLST8 and rictor. Thus, mTORC1 function is essential in early development, mLST8 is required ...
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