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mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation.

Hong(Feng),Larrea(Michelle D),Doughty(Cheryl… Mol Cell 2008-08-01

...TSC2 shRNA, activated SGK1 and p27 phosphorylation at T157, and both were inhibited by short-term rapamycin treatment an...

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis.

Ehninger(Dan),Han(Sangyeul),Shilyansky(Carri… Nat Med 2008-08-21

...Tsc2 gene (Tsc2(+/-) mice) show deficits in learning and memory. Cognitive deficits in Tsc2(+/-) mice emerged in the abs...

Tuberous sclerosis.

Curatolo(Paolo),Bombardieri(Roberta),Jozwiak… Lancet 2008-09-02

...TSC2, encoding hamartin and tuberin respectively. The hamartin-tuberin complex inhibits the mammalian-target-of-rapamyci...

AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in h…

Cao(Cong),Lu(Shan),Kivlin(Rebecca),Wallin(Br… J Biol Chem 2008-12-11

...TSC2-dependent manner. Inhibiting mTOR and positively regulating p53 and p38 might contribute to the pro-apoptotic effec...

AMP-activated protein kinase signaling results in cytoplasmic sequestration of …

Short(John D),Houston(Kevin D),Dere(Ruhee),C… Cancer Res 2008-10-02

Tuberin, the Tsc2 gene product, integrates the phosphatidylinositol 3-kinase/mitogen-activated protein kinase (mitogenic...

Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein p…

Yu(Siwang),Shen(Guoxiang),Khor(Tin Oo),Kim(J… Mol Cancer Ther 2008-10-22

...TSC2 complex by small interfering RNA or gene knockout only partially restored curcumin-mediated inhibition of mTOR and ...

Expression of tuberin and hamartin in tuberous sclerosis complex-associated and…

Grajkowska(Wiesława),Kotulska(Katarzyna),Mat… Folia Neuropathol 2008-07-15

...TSC2, encoding tuberin. Both proteins form a complex inhibiting mTOR signalling pathway and thus regulate cell size and ...

Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosi…

Shigeyama(Yutaka),Kobayashi(Toshiyuki),Kido(… Mol Cell Biol 2008-06-19

...TSC2) as an upstream molecule of mTOR (mammalian target of rapamycin), we examined the effect of TSC2 deficiency on beta...

Acute alcohol intoxication increases REDD1 in skeletal muscle.

Lang(Charles H),Frost(Robert A),Vary(Thomas … Alcohol Clin Exp Res 2008-06-23

...TSC2 complex or the phosphorylation of TSC2 which is down stream in the REDD1 stress response pathway. In contradistinct...

WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4…

Hu(Jian),Zacharek(Sima),He(Yizhou Joseph),Le… Genes Dev 2008-05-13

...TSC2 genes. TSC1 and TSC2 proteins form a functionally interdependent dimeric complex. Phosphorylation of either TSC sub...

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