...TSC2/14-3-3 dissociation and mTORC1 inhibition, while TSC2 mutants that do not bind 14-3-3 are inactive in hypoxia signa...
...TSC2 on 16p13. Both of these genes are tumor suppressor genes encoding hamartin (TSC1) and tuberin (TSC2). Sporadic LAM ...
...TSC2, a constituent of the tuberous sclerosis tumor suppressor protein complex (TSC1/2). TSC1/2 integrates stress signal...
...TSC2 and mTOR-Raptor. The results from our method agreed with experimental results in greater than 90% of the cases cons...
...TSC2 deficient CT-2A mouse astrocytoma cells with syngeneic normal astrocytes that were grown under identical condition ...
...TSC2. Consistent with this pattern, Appl1 is selectively required for cell survival, most critically in highly expressin...
TSC1 and TSC2 are the tumour-suppressor genes mutated in the tumour syndrome TSC (tuberous sclerosis complex). Their gen...
...TSC2, the key negative regulator of mTOR, diminished NF-kappaB but enhanced STAT3 activity and reversed this proinflamma...
...TSC2 complex, the binding of raptor with mTOR, or the phosphorylation of eukaryotic elongation factor-2. However, the in...
...TSC2 gene only. In order to confirm the results in patient tumor samples, the methylation status of the TSC2 gene promot...
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