...Tsc2 function is reduced in mutant axons, indicating cell autonomous defects in signaling. Consistent with signaling pro...
...TSC2 extended into PKD1 showed no evidence of clustering of breakpoints near the polypyrimidine tract.
...TSC2. Moreover the cycloheximide-induced increase in mTORC1 signaling was significantly attenuated in cells lacking REDD...
...TSC2 -mTOR pathway or a guanine nucleotide dissociation inhibitor for the elongation factors EF1A and EF1Bbeta. Accumula...
...TSC2, resulting in mammalian target of rapamycin (mTOR) activation. Hamartomas overgrow epithelial and mesenchymal cells...
...Tsc2 regulates the membrane localization of the glucose transporter proteins (Glut)1, Glut2, and Glut4, and, therefore, ...
...TSC2 gene only. In order to confirm the results in patient tumor samples, the methylation status of the TSC2 gene promot...
...TSC2 suppresses PLD1 activation, whereas the knockdown or deletion of TSC2 leads to elevated basal activity of PLD. Cons...
...Tsc2, which together form the tuberose sclerosis complex that negatively regulates target of rapamycin (TOR) kinase, gav...
...TSC2 mutant cells by transfection of a wild-type TSC2 vector, but not by a TSC2 construct with mutated GSK-3 phosphoryla...
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