...TSC2), insulin receptor (INR) and two insulin-like peptides (ILPs) by quantitative real-time PCR assessment of mRNA leve...
...TSC2 complex, the binding of raptor with mTOR, or the phosphorylation of eukaryotic elongation factor-2. However, the in...
...TSC2 Thr1462, and S6 kinase Thr389 and induced hypertrophy of nonstretched NRVMs. Inhibition of FAK/Src activity by PP2 ...
...TSC2 on 16p13. Both of these genes are tumor suppressor genes encoding hamartin (TSC1) and tuberin (TSC2). Sporadic LAM ...
...TSC2, a constituent of the tuberous sclerosis tumor suppressor protein complex (TSC1/2). TSC1/2 integrates stress signal...
...TSC2 tumor suppressor contributes to suppression of mTORC1; however, TSC2-deficient cells remain responsive to energy st...
...TSC2- and mTOR-independent localization defect of the mutant protein. We conclude that although TSC1 missense mutations ...
...tsc2, indicating that S6K acts downstream or in parallel to TOR in differentiation as in growth. However, loss of eIF4E ...
...TSC2). In the lung, LAM cells found in the vicinity of cysts are, at times, localized in nodules and may be responsible ...
...Tsc2 mutant) rat model of hereditary renal cancer and confirmed the efficacy of gene silencing in vitro. Then, by using ...
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