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Antigen receptor proximal signaling in splenic B-2 cell subsets.

Li(X),Martin(F),Oliver(A M),Kearney(J F),Car… J Immunol 2001-04-26

...Syk protein tyrosine kinase were significantly higher in MZ cells than in FO cells after mIgM engagement, providing a li...

Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-depen…

Stephens(L R),Anderson(K E),Hawkins(P T) J Biol Chem 2001-12-26

...Syk-deficient cell lines but not Btk-deficient cell lines. PI3K-dependent activation of PKB is only lost in Syk-deficien...

A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice.

Hasegawa(M),Fujimoto(M),Poe(J C),Steeber(D A… J Immunol 2001-12-05

...Syk phosphorylation was normal. In addition, the enhanced intracellular Ca(2+) responses following B cell Ag receptor li...

Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activa…

Kraus(M),Pao(L I),Reichlin(A),Hu(Y),Canono(B… J Exp Med 2001-09-20

...Syk tyrosine phosphorylation, and phosphorylation of Igalpha non-ITAM tyrosines. Strikingly, when the Igalpha ITAM mutat...

B cell adaptor containing src homology 2 domain (BASH) links B cell receptor si…

Tsuji(S),Okamoto(M),Yamada(K),Okamoto(N),Goi… J Exp Med 2001-09-20

...Syk- or BASH-deficient B cells. The functional SH2 domain of BASH and Tyr-379 within HPK1 which we identified as a Syk-p...

Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent …

Watanabe(D),Hashimoto(S),Ishiai(M),Matsushit… J Biol Chem 2001-12-04

...Syk are required for activating PLCgamma2, the exact activation mechanism of PLCgamma2 by these kinases has not been est...

CD22 regulates B cell receptor-mediated signals via two domains that independen…

Otipoby(K L),Draves(K E),Clark(E A) J Biol Chem 2001-12-20

...Syk are required for maximal phosphorylation of CD22 following ligation of the BCR, and together Lyn and Syk are require...

Tumour necrosis factor-alpha potentiates CR3-induced respiratory burst by activ…

Forsberg(M),Löfgren(R),Zheng(L),Stendahl(O) Immunology 2001-09-27

...syk). Pretreatment of neutrophils with the inhibitors for p38 MAPK and p72(syk) markedly suppressed the respiratory burs...

Platelet adhesion to fibrinogen coated at various densities.

Jirousková(M),Coller(B S) Ann N Y Acad Sci 2001-08-02

...SYK and FAK than adhesion to high-density coated fibrinogen, and leads to activation of integrin alpha IIb beta 3 on the...

Regulation of B lymphocyte development and activation by Bruton's tyrosine kina…

Khan(W N) Immunol Res 2001-12-31

...Syk, and Bruton's tyrosine kinase (BTK). Upon BCR engagement, these PTKs activate downstream effectors, including transc...

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