...TSC2. At least 495 mutations of TSC1 and TSC2 have been reported. Twenty-two males and 22 females who were diagnosed wit...
...TSC2. TSC2 mutations and loss of heterozygosity have been identified in sporadic lymphangioleiomyomatosis-associated ang...
...Tsc2 mutant) rat model of hereditary renal carcinoma (RC) is an example of a Mendelian dominantly inherited predispositi...
...TSC2 genes. The result suggests that the overexpression of cyclin D1 may play an important role in the tumorigenesis of ...
...TSC2 appears to exclude TSC2 from interacting with HERC1. Disease mutations in TSC2, which result in its destabilization...
...TSC2. The normal cellular proteins encoded by these genes, hamartin and tuberin, respectively, form a heterodimer that s...
...TSC2, result in a similar disease phenotype by disrupting the normal interaction of their protein products, hamartin and...
...TSC2 gene (TSC2+/- rats) to examine the consequences of TSC2 mutations for hippocampal synaptic plasticity. While basal ...
...TSC2-mTOR pathway may underlie increased protein synthesis after resistance exercise. We determined the effect of prior ...
...TSC2. Here, we review recent advances in our understanding of the growth and signaling functions of the TSC1 and TSC2 pr...
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