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Mildly oxidized low density lipoprotein rapidly stimulates via activation of th…

Maschberger(P),Bauer(M),Baumann-Siemons(J),Z… J Biol Chem 2000-08-16

...Syk; the translocation of Src, Fyn, and Syk to the cytoskeleton; and the increase of cytosolic Ca(2+) due to mainly Ca(2...

Alternative antigen receptor (TCR) signaling in T cells derived from ZAP-70-def…

Noraz(N),Schwarz(K),Steinberg(M),Dardalhon(V… J Biol Chem 2000-06-30

...Syk, are observed in Syk(hi)/ZAP-70(-) T cells. However, Syk(hi)/ZAP-70(-) T cells differ from control T cells with resp...

Restoration of thymic development in an Lck(-/-) thymoma overexpressing ZAP-70.

Ulivieri(C),Majolini(M B),Baldari(C T) Mol Immunol 2000-06-29

Thymic development is strictly controlled by Src and Syk family protein tyrosine kinases. The major players in this proc...

Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta recep…

Su(L),David(M) J Biol Chem 2000-06-02

...Syk/ZAP70-specific kinase inhibitor, selectively inhibits the tyrosine phosphorylation of STAT3 and STAT5, but not of ST...

Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling…

Grishin(A),Sinha(S),Roginskaya(V),Boyer(M J)… Oncogene 2000-02-07

...Syk. Wild-type (wt) and syk-deficient cells underwent increased DNA synthesis in response to G-CSF; lyn-deficient cells ...

Distinct contributions of glycoprotein VI and alpha(2)beta(1) integrin to the i…

Kamiguti(A S),Theakston(R D),Watson(S P),Bon… Arch Biochem Biophys 2000-03-15

...syk) is rapidly phosphorylated, but the precise contribution of alpha(2)beta(1) integrin and GPVI to signaling for this ...

Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte colon…

Kasper(B),Tidow(N),Welte(K) Int J Hematol 2000-02-16

...Syk kinases are associated with the G-CSFR in neutrophils from SCN patients with point mutations in the cytoplasmic doma...

Purification and characterization of human Syk produced using a baculovirus exp…

Baldock(D),Graham(B),Akhlaq(M),Graff(P),Jone… Protein Expr Purif 2000-03-09

...syk (Syk) plays an essential role in signaling via a variety of immune and nonimmune cell receptors. Syk is activated in...

H(2)O(2) activity on platelet adhesion to fibrinogen and protein tyrosine phosp…

Belisario(M A),Tafuri(S),Di Domenico(C),Squi… Biochim Biophys Acta 2000-05-02

...syk) and pp125(FAK) tyrosine phosphorylation. Our results demonstrate that: (1) H(2)O(2) does not affect the adhesion of...

Activation of macrophage CD8: pharmacological studies of TNF and IL-1 beta prod…

Lin(T J),Hirji(N),Stenton(G R),Gilchrist(M),… J Immunol 2000-03-09

...Syk kinase demonstrated that TNF, but not IL-1 beta, stimulation by CD8 alpha is Syk dependent. By contrast, protein kin...

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