...TSC2 tumor suppressor gene. Along with TSC1, these two genes behave as expected for tumor suppressor genes with evidence...
...TSC2 gene products, hamartin and tuberin, respectively, will also be considered. Hamartin and tuberin may play functiona...
...TSC2 in the TSC1/TSC2 protein complex, inactivating it; while TSC1/TSC2 has GAP activity for the Rheb GTPase (a member o...
...TSC2 that are mutated in the tuberous sclerosis complex disease. Recently, several laboratories have independently repor...
...TSC2 genes; 75% of cases are sporadic. TSC1 mutations cause a milder disease. Bilateral periventricular nodular heteroto...
...TSC2. Western blot analyses confirmed the deregulation of 14-3-3 proteins upon ectopic overexpression of TSC1 and TSC2. ...
...TSC2, and the small guanosine triphosphatase, Rheb. In cells, mTOR is found in a complex with two other proteins, raptor...
...TSC2). Genes for both loci have been isolated and characterized. The promoters of both genes have not been characterized...
...TSC2 indicated the presence of the novel missense change 3106T-->C, 1036S-->P in all family members with seizures. The f...
...Tsc2 function in the insulin/phosphoinositide 3-kinase (PI3K)/Akt pathway. We have shown that Akt regulates the Tsc1-Tsc...
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